Biyomühendislik Bölümü Tez Koleksiyonu: Recent submissions
Now showing items 21-40 of 98
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Kanser Tedavisinde Gen Susturulması İçin Hyalüronik Asit-Polietilenimin Taşıyıcı Sisteminin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2019)Target-specific delivery of small interfering siRNAs in cancer treatment is one of today's leading research topics. Within the scope of the thesis, effective transport of siRNAs via hyaluronic acid (HA) receptor was carried ... -
Effectiveness Of Single And Dual Release Of Melatonin And Bmp-2 In Bone Homeostasis
(Fen Bilimleri Enstitüsü, 2019)In the present thesis, it was aimed to develop single and dual release systems to achieve the prolonged delivery of melatonin (MEL) and bone morphogenetic protein two (BMP-2) and to investigate their synergistic effect on ... -
Tiyol-Metakrilat Polimerizasyonu ile Affinite Monolitlerinin Sentezi ve Histidin İşaretli Protein İzolasyonunda Kullanımı
(Fen Bilimleri Enstitüsü, 2019-06-19)There are many methods currently available for the purification of proteins. It is important that the purification process is carried out in as little steps as possible, with high purity and in a short time. Therefore, ... -
Akciğer Kanserinde Kannabinoidlerin CB Reseptörleri Aracılı Antiproliferatif ve Proapoptotik Etkisinin Araştırılması
(Fen Bilimleri Enstitüsü, 2019-07-04)Lung cancer is the most common cause of death among all cancers in the world due to its rapid metastasis and late diagnosis. Non-small cell lung cancer (NSCLC) constitutes 80% of lung cancer cases. Endocannabinoids are ... -
Meme Kanseri Hücreleriyle Üç Boyutlu Tümör Modellerinin Geliştirilmesi ve Noç Reseptörü İnhibitörünün Uygulanması
(Fen Bilimleri Enstitüsü, 2019-06-28)Tissue cultures as disease models are indispensable research tools in the preclinical studies. Two-dimensional (2D) culture that composed in the monolayer form cannot bear the extracellular interactions of the natural ... -
Kemik Çimentolarında Yumurta Kabuğu Zarı Proteininin Kullanımı
(Fen Bilimleri Enstitüsü, 2019-10-07)Within the scope of the presented thesis, it is thought that protein doped bone cements promise potential in terms of biodegradability and strength. Therefore, by adding protein to calcium sulphate based bone cements (CSC), ... -
Osseintegrasyonu Arttıracak Hidroksiapatit/Siklodekstrin Kompozit Taşıyıcıların Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2015)ABSTRACT DEVELOPMENT OF HYDROXYAPATITE/CYCLODEXTRIN COMPOSITE CARRIERS TO ENHANCE OSSEOINTEGRATION Meryem Sümeyye AKDEMİR Master of Science, Bioengineering Division Supervisor: Prof. Dr. Menemşe ... -
Hücre Tabakası Mühendisliğinde Kalınlık ve Vaskülerizasyon Problemlerine Yönelik Stratejilerin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2019)In the context of tissue engineering studies, various biomaterials, cells and biosignal molecules have been used to repair and replace diverse tissues either alone or in combination, namely to produce tissue-engineered ... -
SALİNOMİSİN ve BnHAp YÜKLÜ DOKU İSKELELERİNİN ANTİKANSEROJEN ve ANTİBAKTERİYEL ETKİNLİĞİNİN ARAŞTIRILMASI
(Fen Bilimleri Enstitüsü, 2018)In the scope of the thesis, it is aimed to investigate the synergistic effect of an anticancer drug, salinomycin, loaded poly (lactic-co-glycolic acid) (PLGA 65:35) nanoparticles with the boron doped nanohydroxyapatite ... -
Adipoz Kökenli Mezenkimal Kök Hücrelerin Polietilenglikol Dimetakrilat Hidrojellerde Kahverengi ve Beyaz Adipoz Dokuya Farklılaşmalarının İncelenmesi
(Fen Bilimleri Enstitüsü, 2019-02)This study was financially supported by Hacettepe University Scientific Research Projects Coordination Unit with a graduate project entitled “Investigation of Brown and White Adipose Tissue Differentiation of Adipose Derived ... -
3 Boyutlu Yazıcı ile Metakrilatlanmış Jelatin/PRP Hidrojel ve Mezenkimal Kök Hücre İçeren Osteokondral Gradyan Sistemlerin Hazırlanması ve in-Vitro Etkinliklerinin Belirlenmesi
(Fen Bilimleri Enstitüsü, 2019)The aim of the presented doctoral thesis is to develop a gradient hydrogel system which loaded adipos tissue derived stem cells (AdMSCs) by using photoactivated platelet-rich plasma (PRP) gradient and 3D bioprinting method ... -
Hücrelerinden Arındırılmış Miyokardiyal Doku İle Hücre Tabakası Destekli Kalp Yaması Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2019-02)The aim of this thesis is to produce a heart patch by combining cardiovascular cell sheet and decellularized myocardial extracellular matrix (ECM). In the study, two innovative approaches of tissue engineering, ‘‘cell sheet ... -
Development And Characterisation Of Magnetically Responsive And Active Agent Loaded Alginate Based Microspheres To Be Used In The Treatment Of Hepatocellular Carcinoma (Hcc)
(Fen Bilimleri Enstitüsü, 2019)Today, cancer is the foremost common and deadly disease in the world. One of the most important cancer types is liver cancer and occurs either by being directly involved with liver cells resulting in primary liver cancers, ... -
Poli(Poliol)Sebakat Bazlı Biyobozunur Elastomerlerin Sentezi ve Jiro Eğrilmiş Fiber Destekli Hidrojel Doku İskelelerinin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2019)Poly(polyol) sebacate (PPS) based polymers are promising polymers in biomedical and tissue engineering field, thanks to tunable mechanical properties and having biodegradable and biocompatible features. However, difficult ... -
Karaciğer Tümörlerinin Tedavisinde Uygulanacak Y-90 Mikrokürelerin Aktivite Miktarlarının Hastaya Özgü Modelleme İle Belirlenmesi İçin Yöntem Geliştirilmesi ve Yöntemin Standardize Edilmesi
(Fen Bilimleri Enstitüsü, 2019)Yttrium-90 (Y-90) microsphere treatment is the internal radionuclide treatment through administration of Y-90 loaded microspheres to the tumor microcirculation via the relevant branch of the hepatic artery feeding the ... -
Selection and Validation of Aptamers Against Osteosarcoma By Cell-Selex Method
(Fen Bilimleri Enstitüsü, 2019)Osteosarcoma is known as the most common malignant mesenchymal stem cell development by endochondral ossification. Treatment resulting from an early diagnosis of such aggressive pediatric bone cancer can greatly increase ... -
Nerve Guidance Conduit Application Of Magnesium Alloys
(Fen Bilimleri Enstitüsü, 2019)Surgery is insufficient for peripheral nerve injuries larger than 5 mm. Function loss and scar formation occur as a result of slow healing rate and inflammation cells filling the damaged gap. Therefore, isolation of damaged ... -
Development Of Beta-Tricalcium Phosphate Based Injectable Synthetic Bone Graft Materials
(Fen Bilimleri Enstitüsü, 2018)As the global population ages, the number of patients suffering from bone tissue loss due to trauma, degenerative diseases, or surgical intervention increases. To meet the demand for bone graft materials, synthetic substitutes ... -
Dejeneratif Kıkırdak Hasarlarına Yönelik Enjekte Edilebilir Hidrojel Sistemlerinin Geliştirilmesi ve Karakterizasyonu
(Fen Bilimleri Enstitüsü, 2018)Cartilage degeneration is a pathology that develops over time, beginning with the softening of the cartilaginous gland and then completely disappearing. It may be due to trauma, as well as diseases such as osteoarthritis, ... -
Sklera Hasarlarının Rekonstruksiyonunda Otojenik, Allojenik Ve Zenojenik Greftlerin Karşılaştırılması: Yeni Bir Otolog Yaklaşım “Trombositten Zengin Fibrin Membran”
(Fen Bilimleri Enstitüsü, 2018)The purpose of the presented thesis was to compare the effects of xenogenic, allogenic and autogenic graft materials on scleral healing in the repair of scleral tissue damage. For this purpose, scleral tissue damage model ...
