Nörolojik Bilimler ve Psikiyatri Enstitüsü Makale Koleksiyonu
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Short-Hairpin Rna Silencing Of Endogenous Fibroblast Growth Factor 2 In Rat Hippocampus Increases Anxiety Behavior
(Elsevier Science Inc, 2011)Background: The fibroblast growth factor system has been implicated in the pathophysiology of mood disorders in humans and in affective behavior in animal models. However, the studies have been either correlative or involved ... -
The Neurophysiologic Frequency Of Hereditary Neuropathy With Liability To Pressure Palsy In Entrapment Neuropathies
(Türk Nöroloji Derneği, 2016)"Objective: Hereditary neuropathy with liability to pressure palsy (HNPP) needs to be differentiated from entrapment neuropathies due to differences in the treatment management. Materials and Methods: Among 5075 patients ... -
Thrombotic Distal Middle Cerebral Artery Occlusion Produced By Topical Fecl3 Application: A Novel Model Suitable For Intravital Microscopy And Thrombolysis Studies
(Nature Publishing Group, 2011)Intravital or multiphoton microscopy and laser-speckle imaging have become popular because they allow live monitoring of several processes during cerebral ischemia. Available rodent models have limitations for these ... -
What is a Pericyte?
(International Society for Cerebral Blood Flow & Metabolism, 2016)Pericytes, spatially-isolated contractile cells on capillaries, have been reported to control cerebral blood flow physiologically, and to limit blood flow after ischaemia by constricting capillaries and then dying. ... -
Refractory Lesional Parietal Lobe Epilepsy: Clinical, Electroencephalographic and Neurodiagnostic Findings
(Aves, 2016)Introduction: Specialized centers, in the management and surgical treatment of medically refractory epilepsy, emphasize the importance of differentiating the varieties of localization related epilepsies. There has been ... -
Plasma Glycine and Serine Levels in Schizophrenia Compared to Normal Controls and Major Depression: Relation to Negative Symptoms
(Oxford Univ Press, 2004)Previous Studies have suggested decreased N-methyl-D-aspartate (NMDA)-type glutamate receptor function may contribute to increased negative symptoms in patients with schizophrenia. Consistent with this hypothesis, glycine, ... -
Inhibiting 12/15-Lipoxygenase To Treat Acute Stroke In Permanent And Tpa Induced Thrombolysis Models
(Elsevier Science Bv, 2018)12/15-Lipoxygenase (12/15-LOX) contributes to the brain damage after middle cerebral artery occlusion (MCAO) in the acute phase of stroke. The aim of this study was to investigate the effects of a 12/15-LOX inhibitor, ... -
Improving Microcirculatory Reperfusion Reduces Parenchymal Oxygen Radical Formation And Provides Neuroprotection
(Lippincott Williams & Wilkins, 2018)Background and Purpose-Reperfusion is the most significant determinant of good outcome after ischemic stroke. However, complete reperfusion often cannot be achieved, despite satisfactory recanalization. We hypothesized ... -
Inadequate Brain Glycogen Or Sleep Increases Spreading Depression Susceptibility
(Wiley, 2018)Objective: Glycogen in astrocyte processes contributes to maintenance of low extracellular glutamate and K+ concentrations around excitatory synapses. Sleep deprivation (SD), a common migraine trigger, induces transcriptional ... -
Data Of Ascending Cortical Vein Occlusion Induced Spreading Depression
(Elsevier, 2018)The data presented in this article are related to the research article entitled “Microembolism of single cortical arterioles can induce spreading depression and ischemic injury; a potential trigger for migraine and related ... -
Capillary Pericytes Express Α-Smooth Muscle Actin, Which Requires Prevention of Filamentous-Actin Depolymerization For Detection
(eLife Sciences, 2018)Recent evidence suggests that capillary pericytes are contractile and play a crucial role in the regulation of microcirculation. However, failure to detect components of the contractile apparatus in capillary pericytes, ... -
Nuclear Expansion And Pore Opening Are Instant Signs Of Neuronal Hypoxia And Can Identify Poorly Fixed Brains
(Nature Publishing Group, 2018)The initial phase of neuronal death is not well characterized. Here, we show that expansion of the nuclear membrane without losing its integrity along with peripheralization of chromatin are immediate signs of neuronal ... -
Mutations in A Human Robo Gene Disrupt Hindbrain Axon Pathway Crossing and Morphogenesis
(Amer Assoc Advancement Science, 2004)The mechanisms controlling axon guidance are of fundamental importance in understanding brain development. Growing corticospinal and somatosensory axons cross the midline in the medulla to reach their targets and thus form ... -
Neuro-Ophthalmologic Findings In Humans With Quadrupedal Locomotion
(Informa Healthcare, 2012)Purpose: To report the neuro-ophthalmologic findings in four patients from the same family with cerebellar ataxia, mental retardation, and dysequilibrium syndrome (CAMRQ) 2 associated with quadrupedal locomotion. Method: ... -
Mutation Analysis Of The Pink1 Gene In 391 Patients With Parkinson Disease
(Amer Medical Assoc, 2008)Objectives: To determine the frequency, distribution, and clinical features of Parkinson disease (PD) with PINK1 mutations. Design: Retrospective clinical and genetic review. Setting: University hospital. Patients: We ... -
Mitochondrial Dna Analysis in The Turkish Leber'S Hereditary Optic Neuropathy Population
(Royal Coll Ophthalmologists, 2001)Purpose To define the prevalence of a panel of mitochondrial DNA (mtDNA) mutations associated with Leber's hereditary optic neuropathy (LHON) in the Turkish LHON population. LHON-associated mtDNA mutations have been found ... -
Default Mode Network Connectivity Is Linked to Cognitive Functioning and Csf A Beta(1-42) Levels In Alzheimer'S Disease
(Elsevier Ireland Ltd, 2016)Background: Changes in the default mode network (DMN) activity are early features of Alzheimer's disease (AD) and may be linked to AD-specific A beta pathology. Methods: Cognitive profiles; DMN connectivity alterations; ... -
Bilateral Temporal Bone Xanthomas in Type II Hypercholesterolemia
(Turkish Neurosurgical Soc, 2010)We present a very rare case of intracranial xanthoma with bilateral temporal bone involvement. The lesion caused destruction and remodelling in mastoid air cells. On the right side, cerebellar compression was obvious. The ... -
Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis In Two Pairs Of Identical Twins
(Comenius Univ, 2012)The most common pathology in adult patients with temporal lobe epilepsy is hippocampal sclerosis (HS), the etiology of which is not clear. There is a conflicting evidence in literature regarding whether HS is genetic or ... -
12/15-Lipoxygenase Inhibition or Knockout Reduces Warfarin-Associated Hemorrhagic Transformation After Experimental Stroke
(Lippincott Williams & Wilkins, 2017)Background and Purpose For stroke prevention, patients with atrial fibrillation typically receive oral anticoagulation. The commonly used anticoagulant warfarin increases the risk of hemorrhagic transformation (HT) when a ...
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