Anne Sütünde İlaç Kalıntısı ve Postpartum Depresyon İlişkisi

Abstract

Breastmilk is a natural and unique food that is high bioavailability and easy digestion which contains all the liquids, energy and nutrients required for optimum growth and development of the newborn. Mothers are also exposed to unknown sources as well as medical reasons. Postpartum depression (PPD) is a non-psychotic disorder seen postnatally, which can have serious consequences for the baby and the mother. Its etiology is not fully known. The aim of the study is to examine the relationship between the presence of drug residues in mother's milk and maternalinfant characteristics, breastfeeding problems and postpartum depression. Overall, 90 breastfeeding mothers and infants aged between 15 days and 4 months, who applied for child health monitoring, were taken into the study. Maternal height and weight measurements were taken with the mother and information form including maternal-infant characteristics, maternal nutrition characteristics and baby crying and sleep characteristics were filled and maternal milk sample was taken. The average of the mother and infant’s age was 31.5 ± 4.2 years, 57.8 ± 18.1 days, respectively. According to the results of the breast milk residue analysis, 30.0% of the anti-inflammatory drug remnants were found in breastmilk and all of these cases had tolfenamic acid. Quinolone was found in 94.4% of cases, beta-lactam in 93.3%, aminoglycoside in 31.1%, and polymyxin in 13.3%. Spectinomycin remained in 27 out of 28 cases that detected aminoglycoside. There was no effect of the drugs on the residual analysis that used by the mother during pregnancy or lactation. Less postpartum BMI changes observed in mothers who in their’s brest milk antiinflammatory drug residues detected. This was also observed when maternal chronic disease presence, height, weight at birth and birth BMI, smoking history, postnatal period, breastfeeding (alone, mixed nutrition) were controlled (p = 0.049). Higher rate of low birth weight history were found in infants with anti-inflammatory drug residues detected in brestmilk (22.2%, 4.8%, p = 0.011). Despite the fact that more maternal breastfeeding problems were found in the mother who had antiinflammatory drug residues in the mother's milk, this was not statistically significant (48.1%, 28.1%, p = 0.073). Baby's crying and sleeping characteristics did not differ according to the breast milk residue status. Edinburgh postpartum depression score was similar in two groups with and without drug residues in the mothermilk. Our study suggests that there are unpredictable drug residues in the mother's milk, which indicates that mother and baby may affect anthropometric measurements. In this regard, larger participatory studies and contacts are needed. The greater involvement studies are required in this context to contact to resources