Browsing Cerrahi Tıp Bilimleri Bölümü Makale Koleksiyonu by Subject "Plk1"
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Targeting Plk1 Overcomes T-Dm1 Resistance Via Cdk1-Dependent Phosphorylation and Inactivation Of Bcl-2/Xl in Her2-Positive Breast Cancer
(Nature Publishing Group, 2018)Trastuzumab-refractory, HER2 (human epidermal growth factor receptor 2)-positive breast cancer is commonly treated with trastuzumab emtansine (T-DM1), an antibody-drug conjugate of trastuzumab and the microtubule-targeting ...