Hirsutizm ve Serum Çinko Düzeyi Arasındaki İlişkinin Değerlendirilmesi
Özet
The aim of our study was to investigate an association between serum zinc levels and hirsutism. The study was conducted as a cross-sectional and case control study between October 2017 and June 2018 in the Division of Adolescent Medicine Department of Pediatrics in Hacettepe University Ihsan Dogramaci Children`s Hospital. One hundred and two female adolescents between the ages of 12 and 19 years were included. The serum zinc levels of the cases were compared. Estradiol, total testosterone, DHEAS, FSH, LH, SHBG, AS, prolactin levels renal, liver and thyroid function tests were measured in all cases to differentiate hirsutism from other pathologic causes of hirsutism.
Serum zinc levels were measured by the atomic absorption spectrophotometry method. A total of 102 female patients, comprising of 51 patients with hirsutism and 51 healthy adolescents were included in the study. The mean age of the adolescents in the hirsutism group was16,11±1,47 (min-max:12,10-19,0) years and the mean age of the control group was 15,5±1,40 (min-max:12,1117,90) years. The cases were identified as idiopathic hirsutism 37,3%, polycystic ovary syndrome (PCOS) 35,3%and idiopathic hyperandrogenism 27,4%.
The mean zinc level in the hirsutism group was found as 102,57±11,63µg/dl (min-max:79,5-139,05), and as 100,87±16,70 µg/dl (min-max:69,19-146,71 in the control group. There were no statistically significant difference between the two groups. In the comparison of pubic hair stages phase 5 was seen 43 (84,3%) more than controls and other group. There were a correlation between testosteron and LH, FSH,FG scores on the positive side. While menarche age was negatively correlated with estradiol (r=-0,349) (p=0,012) it was positively correlated with androstenedion. It is pointed that androstenedione and testosterone were also positively correlated.
(r=0,657) (p<0,001)
