Tip 2 Diyabetli Hastalarda Serum İrisin Düzeyleri ve Diyet Kalitelerinin Değerlendirilmesi

Abstract

The aim of this study is to investigate the association between serum irisin level, dietary quality and type 2 diabetes mellitus (T2DM). The study was conducted on 80 volunteers who were applied to Endocrinology Department of Keçiören Training and Research Hospital between April 2017 and February 2018 and diagnosed with either T2DM (n:40) or not (n:40). The volunteers were aged between 19-64 and met the study criteria. Age and body mass index (BMI) were matched between the groups. A questionnaire was administered face-to-face in order to determine individuals’ general characteristics, nutritional habits and physical activity status. In order to determine the nutritional status, 24 dietary recall and food frequency questionnaire (based on the last six months) were recorded. Based on these records, Healthy Eating Index (HEI)-2015 scores were calculated. Anthropometric measurements were taken and blood samples were collected during interviews. Serum irisin levels were analyzed from those collected blood samples. The serum irisin level (2.53 ng/mL 95% CI: 2.25-2.99) of the study group was significantly higher than the control group (2.11 ng/mL 95% Cl: 1.93-2.41) (p <0.001). When all data processed without differences between groups, there was a significant positive correlation between age and serum irisin levels (p=0.020), however, there were not any other significant correlations between anthropometric measurements and serum irisin levels (p>0.05). Significantly positive correlation was found between both fasting plasma glucose and HbA1C and serum irisin level (p<0.05). In the study group, HEI-2015 score (48.7 ± 10.67) were found significantly lower than the control group (56.9 ± 11.41) (p=0.001). Though HEI-2015 scores and serum irisin levels were found unrelated (p>0.05). In conclusion, it is thought that serum irisin level may be elevated as a compensatory mechanism against metabolic processes deteriorating in T2DM, and more study is needed in order to have a new approach in the monitoring and treatment of the disease.