Metabolik Sendromlu Hastalarda Makrofaj Apoptoz İnhibitör (AIM), Monosit Kemotaktik Protein-1 (MCP-1) Ve C Reaktif Protein (CRP) Düzeylerinin Değerlendirilmesi

Abstract

Metabolic syndrome is an important health problem that has been shown to be associated with cardiovascular disease and mortality. Although there are many factors that are effective in pathogenesis, recent studies have shown the importance of inflammation in visceral fat tissue. Macrophage apoptosis inhibitor (AIM) and monocyte chemotactic protein (MCP-1) are molecules that cause migrating to visceral fat tissue of M1 macrophages that initiate adipocyte inflammation. C reactive protein (CRP) is a molecule, exhibits the severity of inflammation in the metabolic syndrome and is recommended for use as a biomarker. The aim of this study is to examine serum levels of AIM, MCP-1 and CRP in healthy individuals and metabolic syndrome patients to investigate whether these molecules are a biomarker for the syndrome. For this purpose, 40 metabolic syndrome patients and 40 healthy individuals who were referred to Hacettepe University Faculty of Medicine were included in the study. The mean age was higher in the metabolic syndrome group when there was no gender difference between the groups. Serum AIM, MCP-1 and CRP levels were significantly higher in the metabolic syndrome group. There was a significant positive correlation between serum AIM and CRP levels with waist circumference and body mass index. It was determined that serum levels of these three biomarkers were correlated with each other. The areas under the curve of the serum AIM, MCP-1 and CRP cut off points that could be used in the diagnosis of the metabolic syndrome has been found statistically significant. In addition, serum AIM and CRP levels, above cut-off point were independent risk factors for the metabolic syndrome, whereas serum MCP-1 levels were not independent risk factors. In conclusion the most important determinant of the severity of inflammation in the metabolic syndrome is visceral obesity. AIM and MCP-1 may be effective molecules in the pathogenesis of the metabolic syndrome and its subgroups. Serum AIM, MCP-1 and CRP levels can be used as a biomarker in the diagnosis of metabolic syndrome.