Tip I Diyabetli Çocuklarda Bisfenol-A Maruziyeti ve İdrar Bisfenol-A Düzeyleri

Abstract

In this study, we aimed to evaluate the possible association between BPA exposure and T1DM by comparing the urine BPA levels of children followed up with type I diabetes mellitus with the control group. As a result of the study, urinary BPA levels of the T1DM group were higher than the levels of the control group, but the difference was not statistically significant. In the study group; urinary BPA levels in the children of mothers who consume canned food, UHT milk or water in the plastic bottle were higher than in children of mothers who did not consume. In both groups, urinary BPA levels were significantly higher in the children of the mothers who used the plastic kettle in the home during the prenatal period. In the study group; urine BPA levels were statistically significant in children who used pacifier in infancy period, who live in houses where plastic food containers are used in the kitchen, hot food is stored in these containers and these containers are washed in a dishwasher, who use plastic kettle, who consume dairy products in the plastic box, and prepared foods. When the exposure factors which found to be important in the initial analyses were examined by two-way ANOVA; it was found that canned food consumption of mother during pregnancy, using the plastic kettle, and consumption of dairy products in the plastic box were affecting and increases the urinary BPA levels in all children. When the effects of risky exposure were analyzed by multiple linear regression analysis, only plastic kettle usage was found to increase urinary BPA level in all children independently of the case-control group. As a result, the association between BPA exposure and T1DM was not found. However, the use of a plastic water heater, which is not mentioned in the literature, could be an important risk factor for BPA exposure.