Primer Açık Açılı Glokom ve Eksfoliasyon Glokomunda Progresyonu Etkileyen Risk Faktörlerinin Değerlendirilmesi

Abstract

Our aim in this study is to evaluate the effect of risk factors on progression in Primary Open Angle Glaucoma and Exfoliation Glaucoma. 139 patients who were followed up for POAG and EG in the glaucoma unit of our clinic were included in the study. Age, gender, hypertension, diabetes, thyroid disease, cardiovascular disease, migraine, alcohol, smoking, family history, eye side, lens status, medication number, body mass index (BMI), intraocular pressure (IOP), MD value and surgical history of the patients were recorded. For progression, a change of 1 dB / year or more in MD was accepted. Patients were evaluated according to both regardless of type of glaucoma and in POAG and EG group. Mean MD change was -0,96 ± 1,51 dB / year, mean baseline MD was -5,06 ± 5,61 dB and mean IOP was 15,94 ± 1,93 mmHg in the patients. The patients were divided into two groups; POAG and EG. This two group were divided into progressing and non-progressing groups. Seventy-five (53,9%) of the patients were POAG, 64 (45,9%) were EG. Regardless of type, there was no significant difference for any factor which thought to affect progression between the progressive and non-progressive groups. In the subgroup analyzes, BMI was significantly higher in the group without progression in the POAG group (p = 0,013) and mean IOP was significantly higher in the group with progression in the EG group (p = 0,026). There was no significant difference for the other factors. In the logistic regression analysis; reduction of 1 unit of BMI increased the risk by 1,30 times in the POAG group (p = 0,01). Pseudophakic patient increased risk by 8,33 times (p = 0,016) and smoking was reduced the risk by 6,02 times in the EG group (p = 0,044). Pseudophakic patient increased the risk by 2,45 times (p = 0,032) in the whole group (p = 0,041). In conclusion, we think that reduction in BMI in the POAG group, pseudophakic patient in the EG and the whole group increased the risk of progression.