Doksorubisin ve 5-Florourasil’in Kimyasal İlgi Profilleri, Moleküler Baskılanması, Nanopartiküllerin hazırlanması, Karakterizasyonu ve İlaç Salım Davranışları

Abstract

The interaction dynamics between drug-monomer-solvent is the backbone in the thermodynamic calculation of the molecular imprinting (MIP) and the controlled drug release (CDR) components. Cohesive energy density of components (CED)/resolution parameters (δd, δp, δh) are the important characteristic of desired profile. High chemical affinity establish some problems in controlled release, however, low chemical affinity causes instantaneous releasement. The calculations for choosing the best reactants were done based on the utilization of chemical affinity profiles (Hansen Method). Based on the thermodynamic computational calculations, 2-trifluoromethyl acrylic acid and Hydroxyethyl methacrylate for Doxorubicin and 4-vinylpyridine and acrylic acid for 5-Fluorouracil, were chosen as optimal monomers to synthesize MIPs. In order to increase the release efficiency, these polymers have been imprinted on MWCNT and Fe3O4 nanoparticles (NPs) and were characterized by infrared spectroscopy (FTIR), X-Ray diffraction (XRD), scanning electron microscopy (SEM), elemental analysis (CHN) and thermal analysis (TGA/DSC). The results from HPLC spectroscopy have illustrated the controllable release of the anticancer agents. The applications of these methods have been investigated for controlled drug release (CDR) and determination of trace amounts of anticancer drugs in simulated body fluid (SBF) pH=5.8 and pH=7.4.