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Non-Alkolik Yağlı Karaciğer (NAYKH) Hastalığı Olan Bireylerde Doymuş Yağı Azaltılmış Diyetin İnflamasyon Üzerine Etkisi

dc.contributor.advisorGöktaş, Zeynep
dc.contributor.authorErdem, Nur Bengü
dc.date.accessioned2017-09-05T05:35:31Z
dc.date.available2017-09-05T05:35:31Z
dc.date.issued2017
dc.date.submitted2017-08-07
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Hepatic, adipocyte, enteric and pancreatic hormones: response to dietary macronutrient composition and relationship with metabolism. Nutr Metab (Lond). 2017;14:44tr_TR
dc.identifier.urihttp://hdl.handle.net/11655/3942
dc.description.abstractErdem N.B., Effect of Reduced Saturated Fatty Acid Diet on Inflammation in Non-AlcoholicFatty Liver Disease (NAFLD), Hacettepe University Institue of Health Sciences of Nutritional Sciences, Master of Sciences Thesis, Ankara, 2017.Non-Alcoholic Fatty Liver Disease (NAFLD) is a complex disease that includes from; stetatosis known as a simple fatty liver to Non-Alcoholic Steatohepatitis, having inflamatuar situation and liver cancer.It has been showed that both of fat type and amount plays pioner role at the progression of disease.The aim of this study is to determine effect of reduced saturated fatty acids diet in anthropometric measurements some of biochemical parameters in blood Tumor necrosis factor (TNF) -α, Interleukin (IL)-6 and Chemerin levels in serum in individuals with NAFLD. A total of 23 adults aged between 19 to 65 years participated in the study. In this study regard individuals were randomly dividided into two groups. They followed diet therapy for three months; group with 7 % saturated fatty acid (n=11) 12% saturated fatty acid (n=12). Questionnairre including demographic characteristics,dietary habits, smoking status, alcohol consumption and 24 hour physical activity recall,were applied face to face at baseline. Collected serum samples for TNF-α, IL-6 and chemerin were run in by ELISA. Data of individiuals’s anthropometric measurements, biochemical parameters and serum protein levels were compared at baseline and end of study. Body Mass Index (BMI) decreased from 31,2±3,96 kg〖/m〗^2 to 29,3±4,36 kg〖/m〗^2(p=0,002) in 7 % saturated fatty acid group and from 29,9±3,90 kg〖/m〗^2 to 28,8±3,72kg〖/m〗^2 in 12 % saturated fatty acid group. (p=0,001)These changes were siginificant in statistically. At the end of study ALT, AST, enzyme level changes were significant (p<0,05). In both groups body weight, waist circumference and body fat percentage changes were significant in statistically (p<0,05). However TNF-α, IL-6 and chemerin levels changes weren’t significant in statistically (p>0,05). As a part of routin therapy importance of healthy nutrition should be explained to patients with NAFLD. Healhty nutrition habits can be applied long life should be aimed to patients with NAFLD.tr_TR
dc.description.tableofcontentsONAY SAYFASI iii YAYIMLAMA VE FİKRİ MÜLKİYET HAKLARI BEYANI iv ETİK BEYAN v TEŞEKKÜR vi ÖZET vii ABSTRACT viii İÇİNDEKİLER ix SİMGELER VE KISALTMALAR xi ŞEKİLLER xiii TABLOLAR xiv 1.GİRİŞ 1 1.1. Kuramsal Yaklaşımlar 1 1.2. Amaç ve Varsayımlar 2 2.GENEL BİLGİLER 3 2.1. Non-Alkolik Yağlı Karaciğer Hastalığı ve İnflamasyon 3 2.1.1. Kimerin 4 2.1.2. Tümör Nekroz Faktörü (TNF) -α 6 2.1.3. İnterlökin (IL) -6 7 2.1.4. Visfatin 9 2.1.5. Retinol Bağlayıcı Protein (RBP) -4 9 2.1.6. Leptin 10 2.1.7. Adiponektin 11 2.1.8. Apelin 12 2.1.9. Resistin 12 2.2. Non-Alkolik Yağlı Karaciğer Hastalığı ve Beslenme 13 2.2.1. Doymuş Yağ Asitleri 16 2.2.2. Doymamış Yağ Asitleri 17 3. GEREÇ VE YÖNTEM 23 3.1. Araştırma Yeri, Zamanı ve Örneklem Seçimi 23 3.2. Araştırmanın Genel Planı 23 3.3. Verilerin Toplanması 24 3.4. Verilerin Değerlendirilmesi 28 4. BULGULAR 29 4.1. Bireylerin Genel Özellikleri 29 4.2 Bireylerin Genel Beslenme ve Fiziksel Aktivite Alışkanlıkları 31 4.3 Bireylerin Antropometrik Ölçümleri 33 4.4 Bireylerin Biyokimyasal Parametreleri 38 4.5 Bireylerin Besin Tüketim Kayıtları 41 4.6 Bireylerin Serum İnflamatuar Protein Düzeyleri 48 5. TARTIŞMA 54 5.1 Bireylerin Genel Özellikleri 54 5.2 Bireylerin Genel Beslenme ve Fiziksel Aktivite Alışkanlıkları 54 5.3 Bireylerin Antropometrik Ölçümleri 55 5.4 Bireylerin Biyokimyasal Parametreleri 57 5.5 Bireylerin Besin Tüketim Kayıtları 59 5.6 Bireylerin Serum İnflamatuar Protein Düzeyleri 61 6. SONUÇ VE ÖNERİLER 65 6.1. Sonuçlar 65 6.2 Öneriler 68 7. KAYNAKLAR 70 8. EKLER EK 1. Aydınlatılmış Onam Formu EK 2. Tez Çalışması ile İlgili Etik Kurul İzinleri EK 3. Anket Formu EK 4. Kit Protokolleri 9. ÖZGEÇMİŞtr_TR
dc.language.isoturtr_TR
dc.publisherSağlık Bilimleri Enstitüsütr_TR
dc.rightsinfo:eu-repo/semantics/restrictedAccesstr_TR
dc.subjectNAYKHtr_TR
dc.subjectdoymuş yağ asitleritr_TR
dc.subjectdiyettr_TR
dc.subjectinflamasyontr_TR
dc.titleNon-Alkolik Yağlı Karaciğer (NAYKH) Hastalığı Olan Bireylerde Doymuş Yağı Azaltılmış Diyetin İnflamasyon Üzerine Etkisitr_TR
dc.typeinfo:eu-repo/semantics/masterThesisen
dc.description.ozetErdem N.B., Non-Alkolik Yağlı Karaciğer (NAYKH) Hastalığı Olan Bireylerde Doymuş Yağı Azaltılmış Diyetin İnflamasyon Üzerine Etkisi, Hacettepe Üniversitesi Sağlık Bilimleri Enstitüsü Beslenme Bilimleri Programı, Yüksek Lisans Tezi, Ankara, 2017.Non-Alkolik Yağlı Karaciğer Hastalığı (NAYKH) basit yağlanma olan steatozdan inflamasyon durumunu içeren Non-alkolik steatohepatite ve sonunda karaciğer kanserine uzanan geniş bir aralığı kapsayan kompleks bir hastalıktır. Diyet yağının hem miktar hem de tür açısından hastalığın gelişiminde öncü rol oynadığı gösterilmiştir. Bu araştırmanın amacı (NAYKH) tanısı almış bireylerde doymuş yağı azaltılmış diyetin antropometrik ölçümlere, kanda bazı biyokimyasal parametrelere ve serum Tümör Nekroz Faktörü (TNF)-α, İnterlökin (IL)-6 ve kimerin seviyelerine etkisini saptamaktır. Çalışmaya 19-65 yaş aralığında 23 kişi katılmıştır. Çalışma kapsamında bireylerrandomize iki gruba ayrılarak %7 (n=11) ve %12 (n=12) doymuş yağ içeren diyet tedavisi 3 ay süresince uygulanmıştır. Çalışma başlangıcında bireylere demografik özellikler, diyet alışkanlıkları, sigara ve alkol tüketimi ve 24 saatlik geriye dönük fiziksel aktiviteyi sorgulayan anket yüz yüze uygulanmıştır.Çalışma başlangıcında ve bitiminde serum örneklerinde ELISA kitleriyle TNF-α, IL-6 ve kimerin çalışılmıştır. Bireylerin antropometrik, biyokimyasal parametreleri ile serum inflamatuar protein düzeyleri çalışma başlangıcında ve sonunda karşılaştırılmıştır. Beden Kütle İndeksi değerleri %7 doymuş yağ alan grupta 31,2±3,96 kg〖/m〗^2’den 29,3±4,36 kg〖/m〗^2’ye (p=0,002) %12 doymuş yağ alan grupta ise 29,9±3,90 kg〖/m〗^2’den 28,8±3,72kg〖/m〗^2’ye (p=0,01) düşmüştür. Bu değişimler istatistik açıdan anlamlı bulunmuştur. Çalışma sonunda her iki gruptaki ALT ve AST enzim düzeylerindeki değişim istatistiksel açıdan anlamlı bulunmuştur (p<0,05). Her iki grupta da vücut ağırlığı, bel çevresi ve vücut yağ yüzdesindeki değişim istatistiksel açıdan anlamlı bulunmuştur (p<0,05)Her iki gruptaki bireylerin 0.serum TNF-α, IL-6 ve kimerin düzeylerindeki değişim istatistiksel açıdan anlamlı bulunmamıştır (p>0,05)NAYKH’lı bireylere sağlıklı beslenmenin önemi ve tedavinin bir parçası olduğu anlatılmalı ve bireylere yaşam boyu uygulanabilir sağlıklı beslenme alışkanlıklarını kazandırma hedeflenmelidir.tr_TR
dc.contributor.departmentBeslenme ve Diyetetiktr_TR
dc.contributor.authorID10162667tr_TR


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