Duchenne Musküler Distrofili Çocuklarda Uyku Parametreleri ile Motor Performans, Kognitif Durum ve Pulmoner Fonksiyon Arasındaki İlişkinin İncelenmesi

Abstract

The aim of this study was to investigate the relationship between sleep parameters and motor performance, cognitive status, and pulmonary function in children with Duchenne Muscular Dystrophy (DMD). The study included 32 children with DMD aged 5-12 years, and a functional level of 1-5 according to the Brooke Lower Extremity Classification. The Children Sleep Habits Questionnaire (CSHQ) was used to assess the sleep problems, and the Pediatric Sleep Questionnaire-Sleep Related Breathing Disorders Subscale (PSQ-SRBD) was used to assess the presence of sleep-disordered breathing. Within the scope of motor performance assessments, the 6-minute walk test, muscle strength, timed performance tests, the Energy Consumption Index and the North Star Ambulation Assessment was performed. Cognitive status was assessed with the Modified Pediatric Mini Mental Scale and dual task conditions. Pulmonary function assessments included spirometric evaluations and peak cough flow assessment. The mean age of the children was 8.88±1.95 years. The CSHQ score was 43.81±5.44 points, indicating sleep disturbance and 62.5% of children had sleep problems. The PSQ-SRBD score was 0.2 (0.09-0.3) points, indicating no significant SRBD risk and SRDB was observed in 15.6% of children. No association was found between sleep problems and motor performance, cognitive status and pulmonary function (p>0.05). In conclusion, it was found that sleep problems were observed to a great extent in children with DMD, but there was no correlation between sleep disturbance and most of the clinical parameters. The results of the study showed that sleep screening should be carried out in children with DMD at an early stage, before any deterioration in clinical parameters is expected.