Polikistik Over Sendromu Tanılı Kadın Bireylerde Diyetin İnflamatuar İndeksinin CD36 ve Kardiyometabolik Risk Faktörleri Üzerine Etkileri

Abstract

This study was planned and conducted to investigate the effects of dietary inflammatory index (DII) on CD36 and cardiometabolic risk factors in women with polycystic ovary syndrome (PCOS). The research was carried out on 38 women with PCOS 39 healthy women as a control group. A questionnaire containing general information was applied and their anthropometric and blood pressure measurements and food frequencies questionnaire were taken to the participants in the early follicular phase of their menstrual cycle. Participants’ daily energy and nutrient consumption was calculated and then the DII was calculated. Additionally, biochemical data related to glucose regulation, lipid profile, and sex hormone profile were recorded, and serum levels of hs-CRP and CD36 were analyzed by ELISA method. The PCOS and control groups included in the study consist of participants similar in terms of age (21.6±2.26 and 21.1±1.81 years, respectively) and BMI (26.3±4.20 and 25.9±3.22 kg/m2) (p>0.05). It was observed that the DII value was not different between groups matched in terms of age and BMI (p>0.05). Similarly, although hs-CRP and CD36 levels were mathematically higher in the PCOS group, this difference was not found to be significant (p>0.05). Moreover, it was found that DII values of individuals were positively correlated with fasting blood glucose, blood pressure values, hs-CRP, and CD36 levels. Furthermore, serum CD36 levels were found to be negatively correlated with waist circumference, total testosterone, fasting insulin levels, and HOMA-IR value in both PCOS and control groups, while CD36 levels were positively correlated with hs-CRP, daily carbohydrate and fat intake (p<0.05). Additionally, logistic regression analysis revealed that DII value, DII quartiles, and CD36 levels did not significantly increase the risk for the development of PCOS (p>0.05). Taken together, these data suggest that DII value and CD36 may exert different effects on cardiometabolic risk factors in women with PCOS through different mechanisms. In this context, it is thought that increasing the amounts of anti-inflammatory foods and reducing the consumption of pro-inflammatory foods may have beneficial effects on PCOS and related metabolic problems. However, more comprehensive studies related to the effects of diet on inflammation and metabolic pathways in women with PCOS are needed.