Ağrı Merkezlerinin Kortikal Nöroanatomisinin Volümetrik Ölçümü
Özet
The aim of this study is to perform whole brain morphometric analysis of pain centers radiologically in normal individuals and to evaluate the values obtained from cortical structural models for diagnostic biomarker research in further studies. Thus, to standardize the volumetric values of pain centers in normal individuals. For this purpose, after obtaining ethical approval, the data of patients aged 18-65 years without any comorbidity, intracranial pathology and who underwent volumetric sequence cranial MRI were retrospectively evaluated. The volBrain application was used for volumetric measurement of pain-related central centers. In our study, 19 pain-related parameters were analyzed. Volumetric measurements were performed in 55 adults, 27 males and 28 females. The main results were as follows: Thalamus volume - males: 13.33 ± 1.29 cm³, females: 12.12 ± 0.85 cm³ (p < 0.001). Postcentral gyrus volume - males: 20.40 ± 2.68 cm³, females: 18.82 ± 0.85 cm³ (p = 0.025). Anterior Cingulate Cortex volume - males: 12.21 ± 1.87 cm³, females: 11.25 ± 1.71 cm³ (p = 0.38). Medial Cingulate Cortex volume - males: 11.39 ± 1.48 cm³, females: 10.54 ± 1.38 cm³ (p = 0.028). Gyrus parahippocampalis volume - males: 6.58 ± 0.80 cm³, females: 5.60 ± 0.63 cm³ (p < 0.001). Insula anterior volume - males: 9.01 ± 1.11 cm³, females: 8.41 ± 1.00 cm³ (p = 0.047). The statistically significant difference between the sexes was thought to be due to constitutional characteristics. In conclusion, the database obtained forms the basis of a reference database for analyses of the variability of these structures. In the current era of neuroimaging, neuroscience and functional neurosurgery, the correct interpretation of reference values (current volumetric standardization) can make a significant contribution to the diagnosis and treatment of patients with pain.
