KİLO FAZLALIĞI VE OBESİTESİ OLAN ERGENLERDE TIKINIRCASINA YEMENİN METABOLİK PROFİLE ETKİSİ

Abstract

Faruk Seyfettin ÇETİN, The Effect of Binge Eating on the Metabolic Profile in Adolescents with Overweight or Obesity, Hacettepe University İhsan Doğramacı Children's Hospital, Department of Children’s Health and Diseases, Thesis of Pediatrics, Ankara, 2023. Binge eating negatively affects the inflammatory and metabolic profile in adults by leading to the intake of high-calorie foods rich in simple sugar and fat, in a short time. Data in adolescents are limited and contradictory. For this purpose, this study aimed to compare the metabolic and inflammatory parameters of adolescents with and without binge eating (BE) or binge eating disorder (BED) and to investigate the relationship between BED and metabolic syndrome. Eighty-two adolescents with overweight or obesity between the ages of 12 and 18, who presented to the Hacettepe University İhsan Doğramacı Children's Hospital Adolescent Medicine Clinic between April 2022 and September 2023, were included in the study. The patients' waist circumference, BMI z-score, systolic and diastolic blood pressure measurements were obtained. Fasting and postprandial glucose, fasting and postprandial insulin, hemoglobin-A1C, triglyceride, HDL, LDL, total cholesterol, CBC, ALT, AST, TSH, free thyroxine, ESR, CRP values were measured. The Munich Eating and Nutritional Disorders questionnaire was used to evaluate the presence of BE attacks and BED. We found that BE attacks were more common in women. Elevated systolic or diastolic blood pressure is more common in adolescents with BE. All patients who meet four or more metabolic syndrome criteria are in the BE group. The metabolic and inflammatory parameters were similar between the groups and no association was found between the presence of metabolic syndrome and BED. When the results of our study are evaluated in alignment with adult data, BE has not yet caused a significant deterioration in metabolic and inflammatory parameters during the adolesent period of life, except for high blood pressure. However, BE might increase the risk of developing metabolic syndrome over time. As high blood pressure may be an early indicator of BE-related metabolic deterioration, it is important to question BE attacks in overweight or obese adolescents with detected elevated blood pressure. Early diagnosis and treatment of BED during adolescence may be beneficial in preventing future metabolic complications.