Akut Yüksek Şiddetli Aralıklı Egzersiz ve Orta Şiddetli Sürekli Egzersizin Speksin ve Leptin Düzeylerine Etkisi

Abstract

Regular physical activity and exercise play a crucial role in promoting overall well-being and improving health. For individuals with time constraints, high-intensity interval exercise (HIIE) is emerging as a valuable alternative. The fact that the health benefits of HIIE are equivalent to or greater than those of traditional moderate-intensity continuous exercise (MICE) suggests that this exercise model can be incorporated into individualized exercise prescriptions. Exercise exerts some of its health benefits through molecules called exerkines, which are released in response to acute or chronic exercise. Spexin, which is involved in many physiological processes such as appetite, weight control and glucose metabolism, is an exerkin that interacts with leptin. The aim of this study is to examine the effects of HIIE and MICE protocols with equalized total workload on serum spexin and leptin levels. Nineteen physicaly active young males (mean age: 25.7 ± 5.5 years; body weight: 73.3 ± 7.7 kg; height: 176,6 ± 6,2 cm; maximal oxygen consumption (VO2max): 44,5 ± 4,7 ml/min/kg) participated in HIIE and MICE sessions on a bicycle ergometer. The HIIE session consisted of 10x1 min of high-intensity exercise intervals at 90% of VO2max separated by 75 second of active recovery periods at 60 watts. The MICE session consisted of continuous cycling at 55% of VO2max, equal to the total workload achieved in the HIIE session. Venous blood samples were taken before, immediately after and 1 hour after each exercise session. Serum spexin and leptin concentrations were determined by enzyme linked immunosorbent assay (ELISA). Two-way analysis of variance (ANOVA) with repeated measures was used for statistical analysis of the data. Immediately after acute HIIE and MICE, serum spexin (HIIE: 174,32 ± 48,21; MICE: 186,53 ± 56,74 pg/ml) and leptin (HIIE: 335,98 ± 137,55; MICE: 302,94 ± 150,88 pg/ml) levels increased compared to baseline values (p<0.05). There was no significant difference between the effects of the two exercise protocols on serum spexin and leptin levels (p>0.05). In both exercise protocols, serum levels of spexin (HIIE: 156,63 ± 46,22; MICE: 165,79 ± 60,74 pg/ml) and leptin (HIIE: 273,71 ± 109,09; MICE: 264,71 ± 120,77 pg/ml) decreased to baseline levels 1 hour after exercise (p<0.05). The results of this study show that acute high-intensity intermittent exercise and moderate-intensity continuous exercise concentrations in active young males result in increased serum concentrations of spexin and leptin regardless of the exercise protocol. However, the levels of both molecules return to baseline levels 1 hour after the end of exercise.