Glikoprotein Non-Metastatik Melanoma Protein B (GPNMB), Kan Glukoz Düzeyi ve Karaciğer Yağlanması Arasındaki İlişkinin İncelenmesi

Abstract

Although the functions and role of GPNMB, which has been shown to be secreted from the liver and accepted as a hepatokine, and its role in energy balance are not yet known, it is thought to play a role in the communication between the liver and adipose tissue. Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. NAFLD is often associated with abdominal obesity, insulin resistance, hypertension, and dyslipidemia, so the metabolic syndrome is the main risk factor for NAFLD. Defining the relationship of GPNMB with prediabetes and fatty liver is important to understand the physiopathological processes in the metabolic syndrome and the functions of hepatokines. The aim of this study is to examine the relationship between GPNMB and blood glucose level and fatty liver. For this purpose, 61 volunteers between the ages of 30-55, who do not smoke, do not use drugs, and do not have any systemic disease were included in the study. Subjects were divided into 4 groups according to their gender and body mass index as normal weight female (n=16), overweight female (n=16), normal weight male (n=13) and overweight male (n=16). Fasting blood glucose, insulin, serum GPNMB, lipid profile, ALT, AST, T4, TSH, ESR, CRP, HbA1c measurements were performed in blood samples taken from the subjects after 12 hours of fasting. Afterwards, 75 grams of oral glucose loading test was performed on the subjects and blood glucose, insulin level and GPNMB levels were measured again in the blood samples taken at 30, 60, 90 and 120 minutes. Blood pressure and detailed body analysis measurements of the subjects were made. Liver size, adiposity and stiffness were evaluated by upper abdomen magnetic resonance imaging. As a result of our study, no relationship was found between serum GPNMB levels and blood glucose level, insulin level, HbA1c, liver size, adiposity and stiffness. There was no difference between normal weight and overweight subjects in terms of GPNMB levels. These results suggest that blood GPNMB level is not a direct indicator of changes in blood glucose level, body mass index, or fatty liver in healthy individuals.