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2,2,7,7-TetraMethyl-1,2,3,4,5,6,7,8-OctaHydroAcridine-1,8-Dione
(2012)The whole molecule of the title compound, C17H21NO2, is generated by twofold rotational symmetry. The N atom and the C and H atoms in position 4 of the pyridine ring lie on the twofold axis. The cyclohexene ring has a sofa ... -
3,3,6,6-TetraMethyl-9-(1-Methyl-1H-Indol-2-Yl)-1,2,3,4,5,6,7,8,9,10-DecaHydroAcridine-1,8-Dione
(2012)In the acridine system of the title molecule, C26H30N2O2, both cyclohex-2-enone rings adopt sofa conformations. The indole ring system is essentially planar, with a maximum deviation of 0.017 (2) Å for a bridgehead C ... -
9-(5-Bromo-1H-Indol-3-yl)-1,2,3,4,5,6,7,8,9,10-Decahydroacridine-1,8-Dione Dimethyl Sulfoxide Monosolvate
(2012)In the title compound, C21H19BrN2O2·C2H6OS, the indole ring system is essentially planar, with a maximum deviation of 0.050 (3) Å for the non-bridgehead C atom adjacent to the N atom. The two cyclohex-2-enone rings adopt ... -
A New Generation Of Dihydropyridine Calcium Channel Blockers: Photostabilization Of Liquid Formulations Using Nonionic Surfactants
(2019)The stability profile of a new 1,4-dihydropyridine derivative (DHP), representative of a series with a hexahydroquinoline ring, was studied to design light-stable liquid formulations. This molecule, named M3, has been shown ... -
A New Perspective On Evaluation Of Medicinal Plant Biological Activities: The Correlation Between Phytomics And Matrix Metalloproteinases Activities Of Some Medicinal Plants
(2019)Phytomics or metabolomics is analysis of large-scale primary and secondary metabolites of plant extracts and provides very meaningful data to monitor or evaluate cellular function or systems biology. The activity of plant ... -
Aloe-Emodin As Drug Candidate For Cancer Therapy
(2018)As a leading cause of global mortality, cancer frequently cannot be cured due to the development of drug resistance. Therefore, novel drugs are required. Naturally occurring anthraquinones are mostly present in Rumex and ... -
Anti-Cancer Effects of 3,5-Dimethylaminophenol in A549 Lung Cancer Cells
(2018)Exposure to 3,5-dimethylaminophenol (3,5-DMAP), the metabolite of the 3-5-dimethylaniline, was shown to cause high levels of oxidative stress in different cells. The aim of the present work was to observe whether this ... -
Antigenotoxic Properties of Paliurus Spina-Christi Mill Fruits and Their Active Compounds
(2017)Background Paliurus spina-christi Mill. (PS) fruits are widely used for different medical purposes in Turkey. Like in many medicinal herbs the studies concerning their activity, the activities of PS are also not well ... -
Assessing Medical Prescription Forms As A Communication Tool In Trans-European Health Care
(2018)Objective: The objective of the study was to compare the medical prescription forms in European Union (EU) countries, evaluating their convergence toward the implementation of cross-border care, as proposed by the existing ... -
Characterization Of Volatile Compounds Of Eleven Achillea Species From Turkey And Biological Activities Of Essential Oil And Methanol Extract Of A. Hamzaoglui Arabacı & Budak
(2015)According to distribution of genus Achillea, two main centers of diversity occur in S.E. Europe and S.W. Asia. Diversified essential oil compositions from Balkan Peninsula have been numerously reported. However, report on ... -
Chronopharmacodynamics Of Drugs In Toxicological Aspects: A Short Review For Clinical Pharmacists And Pharmacy Practitioners
(2012)For many decades, researchers are aware of the importance of circadian rhythm in physiological/biochemical properties and drug metabolism. Chronopharmacology is the study of how the effects of drugs vary with biological ... -
Chronopharmacokinetics Of Drugs In Toxicological Aspects: A Short Review For Pharmacy Practitioners
(2012)A rough 24-hour cycle driven endogenously in biochemical, physiological or behavioral processes is called circadian rhythm. Chronobiology is the study of biological temporal rhythms. For decades, we know that the biological ... -
Comparative Studies On Phenolic Composition, Antioxidant, Wound Healing And Cytotoxic Activities Of Selected Achillea L. Species Growing In Turkey
(2015)Turkey is one of the most important centers of diversity for the genus Achillea L. in the world. Keeping in mind the immense medicinal importance of phenols, in this study, three species growing in Turkey, A. coarctata ... -
Cuscuta Arvensis Beyr “Dodder”: In Vivo Hepatoprotective Effects Against Acetaminophen-Induced Hepatotoxicity In Rats
(2018)Cuscuta arvensis Beyr. is a parasitic plant, and commonly known as “dodder” in Europe, in the United States, and “tu si zi shu” in China. It is one of the preferred spices used in sweet and savory dishes. Also, it is used ... -
Direct Enantiomeric Resolution Of Seventeen Racemic 1,4-Dihydropyridine-Based Hexahydroquinoline Derivatives By Hplc
(2019)1,4-Dihydropyridine (DHP) scaffold holds an outstanding position with its versatile pharmacological properties among all heterocyclic compounds. Although most of the commercially available DHPs are marketed as a racemic ... -
Discovery And Characterisation Of Dual Inhibitors Of Tryptophan 2,3-Dioxygenase (Tdo2) And Indoleamine 2,3-Dioxygenase 1 (Ido1) Using Virtual Screening
(2019)Cancers express tryptophan catabolising enzymes indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO2) to produce immunosuppressive tryptophan metabolites that undermine patients’ immune systems, leading ... -
Effects Of Developmental Exposure To Silver In Ionic And Nanoparticle Form: A Study In Rats
(2016)Background Evaluations of silver in both nanoparticle (Ag-NPs) and ionic forms indicate some adverse effects on living organisms, but little is known about their potential for developmental toxicity. In this study, ... -
Endocannabinoid System In The Airways
(2019)Cannabinoids and the mammalian endocannabinoid system is an important research area of interest and attracted many researchers because of their widespread biological effects. The significant immune-modulatory role of ...