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The Operational Multiple Dosing Half-Life: A Key To Defining Drug Accumulation In Patients And To Designing Extended Release Dosage Forms
(Springer/Plenum Publishers, 2008)
Half-life (t (1/2)) is the oldest but least well understood pharmacokinetic parameter, because most definitions are related to hypothetical 1-compartment body models that don't describe most drugs in humans. Alternatively, ...
Thrombus Localization By Using Streptokinase Containing Vesicular Systems
(Taylor & Francis Ltd, 2006)
Our research focused on the preparation of vesicular drug delivery systems, such as liposomes, noisomes, and sphingosomes, for achieving slow release of entrapped proteins in the circulation to increase half-life, to mask ...
Development Of A Peptide-Containing Chewing Gum As A Sustained Release Antiplaque Antimicrobial Delivery System
(Springer, 2007)
The objective of this study was to characterize the stability of KSL-W, an antimicrobial decapeptide shown to inhibit the growth of oral bacterial strains associated with caries development and plaque formation, and its ...
Estimation Of Aqueous Distributional Spaces In The Dual Perfused Rat Liver
(Cambridge Univ Press, 2000)
1. The aim of this study was to estimate the aqueous distributional spaces of the liver as a function of the route of input: portal vein (PV) versus hepatic artery (HA). 2. Studies were performed in the in situ single (PV) ...
Preparation and Characterization of Salmon Calcitonin-Biotin Conjugates
(Springer, 2008)
This study was performed to prepare and characterize the biotinylated Salmon calcitonin (sCT) for oral delivery and evaluate the hypocalcemic effect of biotinylated-sCTs in rats. Biotinylated sCTs was characterized by using ...
Preparation and in Vitro Evaluation Of Bfgf-Loaded Chitosan Nanoparticles
(Taylor & Francis Inc, 2007)
The objective of our study was to prepare and characterize basic fibroblast growth factor (bFGF)-loaded nanoparticles. Protein-loaded chitosan nanoparticles were obtained by ionotropic gelation process based on the interaction ...
Increased Levels Of Nitric Oxide, Cortisol And Adrenomedullin In Patients With Chronic Schizophrenia
(Karger, 2007)
Objective: To investigate the levels of serum cortisol, dehydroepiandrosterone sulfate (DHEA-S), nitric oxide (NO) and adrenomedullin (AM) in schizophrenic patients. Subjects and Methods: Sixty-six male patients with chronic ...
In Vivo And In Vitro Effects Of A Hif-1 Alpha Inhibitor, Rx-0047
(Wiley, 2008)
HIF-1 alpha plays a major role in activating gene transcription and is important for maintaining homeostasis under hypoxic conditions. Since tumors are often in a hypoxic state, HIF-1 alpha is a potential target for the ...