Kolşisinin deneysel septik şok modelinde gözlenen mezenterik hipoperfüzyon, organ hasarı ve sistemik inflamasyona etkileri

Abstract

Sepsis remains to be the leading cause of death worldwide. Despite intensive research to improve treatment and survival, few new effective treatments have been identified. Colchicine, a herbal alkaloid, is used to treat gout attacks and many inflammatory conditions. There is little information in the literature about the effects of dose-dependent effects of colchicine on LPS induced sepsis rat model. In this study, we aimed to evaluate the short-term effects of colchicine at different doses in the experimental sepsis model induced by LPS in rats. The possible effects of colchicine treatment at 3 different doses (0.5, 1 mg/kg and 5 mg/kg) on decreased mesenteric blood flow and organ damage in the rat experimental septic shock model by using in vitro and in vivo experimental setups. The levels of proinflammatory cytokines IL- 1β, IL-6, IL- 8, IL-10, IL-17 and TNF-α were measured in heart, liver, spleen tissues and serum. As a result of the experiments, it was observed that biochemical and immunological inflammatory marker levels increased with LPS, and colchicine showed a protective effect with antiinflammatory activity at a dose of 1 mg/kg. High doses of colchicine have been observed to increase inflammation and organ damage. It is thought that colchicine has a reducing effect