Anne sütünde bisfenol a ve d vitamini düzeyleri arasındaki ilişki

Abstract

An endocrine disruptor Bisphenol A (BPA) is widely used in daily life and it is suggested that one of its negative effects on human health may be on vitamin D (vitD) metabolism. In this study, it was aimed to investigate the relationship between breast milk BPA exposure and 25(OH)vitamin D levels. Seventy mothers and their term babies who applied to Hacettepe University İhsan Doğramacı Children's Hospital Healthy Child Polyclinic and gave consent for the study were included in the study. The possible factors that increase the prenatal BPA exposure of the mothers, the birth weight of the baby, the gestational week, the age of the mother, the number of pregnancies, pre- and postnatal weights and heights were recorded with the questionnaire form. Breast milk 25(OH)vitamin D and BPA levels were studied and their levels were divided into low, medium and high groups. The mothers were on average 31,9 years old, while the babies were 62 days old. The median 25(OH)vitamin D levels in breast milk of the cases was 12,6 ng/mL. It was observed that variable factors related to pregnancy, mother and baby had no effect on 25(OH)vitamin D and BPA levels. BPA was detectable in 92,9% of breast milk, and the median BPA level was 2,56 ng/mL. No correlation was found between breast milk BPA and 25(OH)vitamin D levels. (r=0,01, p=0,964). When maternal and infant characteristics were controlled, no correlation was found between the BPA level groups 25(OH)vitamin D being in the upper 33%, and 25(OH)vitamin D being in the upper 33% of BPA. There is no significant relationship between breast milk BPA and 25(OH)vitamin D levels in healthy mother- infant couples.

Key words: Breast milk, Bisphenol A, vitamin D, Endocrine disruptor

This study was supported by Hacettepe University Scientific Research Projects Unit. THD-2021-19566