The Effects of 10 Weeks of Aerobic Exercise Training on Angiotensin (ACE) and Adrenergic Receptor Beta 2 (ADRB2) Gene Expression, Circulating Level of Angiotensin II and Flow Mediated Dilation in Obese Postmenopausal Women with Prehypertension.

Abstract

The effects of 10 weeks of aerobic exercise training on angiotensin (ACE) and adrenergic receptor beta 2 (ADRB2) gene expression, circulating level of angiotensin II and flow mediated dilation in obese postmenopausal women with prehypertension. Graduate School of Health Sciences Sport Sciences and Technology Doctoral Dissertation, Ankara, 2015. Menopause, obesity, physical inactivity and genetic predisposition are the major risk factors for high blood pressure (BP) in women. In postmenopausal women (PMW), reduction in estradiol and estrogen/testosterone ratio as well as obesity leads to activation of sympathetic nervous system, renin-angiotensin system, and endothelial dysfunction that are associated with hypertension. Moderate intensity aerobic exercise training (AET) is known as important modality in the prevention and treatment of hypertension.