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dc.contributor.authorGurbanov, A
dc.contributor.authorGülhan, B
dc.contributor.authorKuskonmaz, Baris
dc.contributor.authorOkur, fatma visal
dc.contributor.authorozaltın, f
dc.contributor.authordüzova, a
dc.contributor.authorcetinkaya, Duygu
dc.contributor.authorToplaoğlu, R
dc.date.accessioned2022-10-12T13:13:45Z
dc.date.available2022-10-12T13:13:45Z
dc.date.issued2022-05
dc.identifier.urihttps://doi.org/10.1007/s00467-022-05599-x
dc.identifier.urihttp://hdl.handle.net/11655/26892
dc.description.abstractBackground This study aimed to determine incidence of kidney complications in pediatric allogeneic hematopoietic stem cell transplantation (HSCT) patients. Methods Pediatric allogeneic HSCT patients were included. Post-transplantation urinary system complications were collected from medical records and glomerular filtration rates at last visit compared with clinical parameters. Additionally, 24-h ambulatory blood pressure monitoring was performed. Results The study included 165 pediatric patients. Acute kidney injury (AKI) developed in 125 (75.8%) patients of whom 54 (43.2%) had stage 1, 36 (28.8%) stage 2, and 35 (28%) stage 3 AKI. Primary malignant disease and viral infection post- HSCT were associated with increased risk of AKI (OR: 4; 95%CI: 1.2–13, p = 0.022 and OR: 2.9; 95%CI: 1.2–6.8, p = 0.014, respectively). Mean duration of post-HSCT follow-up was 4.4 ± 2.5 years, during which time 8 patients had chronic kidney disease (CKD) (stage 1, 4 patients; stage 2, 3 patients; stage 3, 1 patient). CKD incidence was higher in patients in whom stem cell product was bone marrow + cord blood and mobilized peripheral blood, compared to bone marrow alone (40–37.5% versus 5.1%, p = 0.002). Based on 24-h ABPM, 14.7% and 7.4% of patients with normal office blood pressure had pre-hypertension and hypertension, respectively. In patients with albuminuria/severe albuminuria, daytime and nighttime systolic SDS scores were higher than those without albuminuria/severe albuminuria (p = 0.010 and p = 0.004, respectively). Conclusions Incidence of AKI is higher in pediatric HSCT patients with primary malignant disease and those with documented viral infection. Our study highlights the beneficial role of 24-h ABPM as a routine part of standard care of pediatric HSCT recipients.tr_TR
dc.language.isoentr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subjectHSCTtr_TR
dc.titlePredictors of kidney complications and analysis of hypertension in children with allogeneic hematopoietic stem cell transplantationtr_TR
dc.typeinfo:eu-repo/semantics/articletr_TR
dc.relation.journalPediatr Nephroltr_TR
dc.contributor.departmentÇocuk Sağlığı ve Hastalıklarıtr_TR
dc.description.indexWoStr_TR
dc.fundingYoktr_TR


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