Bir Lokal Anestezik Madde Olan Lidokain'in (2-Dıethylamıno-N-(2,6 Dımethylphenyl) Acetamıde) Etki Süresini Uzatmak için Poli Akrilat Bazlı Hidrojel Mikrokürelerin Kullanımı ve Denenmesi

Abstract

Local anaesthetics are used in many space, especially surgial operation in small areas. However, their effect time is short, they need to be repeated continuously and this may cause toxicity that results in many problems. Microspheres are mechanisms that provide controlled release. In this study, prolonging the activity period of lidocaine as a local anaestheticFor the calculation of effect time of microspheres, walking track analysis was made on the rats. Sprague Dawley rats were chosen randomly and they were separated into two groups as control group (n=6) and experimental group (n=6). Both control and experimental groups were injected to their sciatic nerves on their right back legs. As a result, there were significant differences betweeen two groups. is purposed.After that, Compound Motor Action Potentials were quantified. Also for this, Sprague Dawley rats were chosen randomly and they were separated into two groups again as control group (n=3) and experimental group (n=3).