Temel Eczacılık Bilimleri Bölümü Makale Koleksiyonu: Recent submissions
Now showing items 61-80 of 123
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Lactoferrin In Gingival Crevicular Fluid And Peripheral Blood During Experimental Gingivitis
(2009)Objectives Lactoferrin (LF) is an iron binding protein and stored in the specific granules of granulocytes. It is released by degranulation following granulocyte activation. A positive correlation was previously reported ... -
Investigating the Structural Influence of Surface Mutations on Acetylcholinesterase Inhibition by Organophosphorus Compounds and Oxime Reactivation
(Elsevier Ireland Ltd, 2010)Organophosphates (OPs) exert their toxicity by inhibiting primarily acetylcholinesterase (AChE) and to a lesser extent butyrylcholinesterase (BChE). Binary mixtures of mammalian AChE and oximes of varying structure have ... -
Induction Of Telomere Dysfunction Mediated By The Telomerase Substrate Precursor 6-Thio-2'-Deoxyguanosine
(Amer Assoc Cancer Research, 2015)The relationships between telomerase and telomeres represent attractive targets for new anticancer agents. Here, we report that the nucleoside analogue 6-thio-2'-deoxyguanosine (6-thio-dG) is recognized by telomerase and ... -
Increased Levels Of Nitric Oxide, Cortisol And Adrenomedullin In Patients With Chronic Schizophrenia
(Karger, 2007)Objective: To investigate the levels of serum cortisol, dehydroepiandrosterone sulfate (DHEA-S), nitric oxide (NO) and adrenomedullin (AM) in schizophrenic patients. Subjects and Methods: Sixty-six male patients with chronic ... -
In Vivo And In Vitro Effects Of A Hif-1 Alpha Inhibitor, Rx-0047
(Wiley, 2008)HIF-1 alpha plays a major role in activating gene transcription and is important for maintaining homeostasis under hypoxic conditions. Since tumors are often in a hypoxic state, HIF-1 alpha is a potential target for the ... -
In Vivo Inhibition Of Lung Cancer By Grn163L: A Novel Human Telomerase Inhibitor
(Amer Assoc Cancer Research, 2005)Differential regulation of telomerase activity in normal and tumor cells provides a rationale for the design of new classes of telomerase inhibitors. The telomerase enzyme complex presents multiple potential sites for the ... -
In Cellulo Examination Of A Beta-Alpha Hybrid Construct Of Beta-Hexosaminidase A Subunits, Reported To Interact With The Gm2 Activator Protein And Hydrolyze Gm2 Ganglioside
(2013)The hydrolysis in lysosomes of GM2 ganglioside to GM3 ganglioside requires the correct synthesis, intracellular assembly and transport of three separate gene products; i.e., the alpha and beta subunits of heterodimeric ... -
Hplc Method Development For The Simultaneous Analysis Of Amlodipine And Valsartan In Combined Dosage Forms And In Vitro Dissolution Studies
(Univ Sao Paulo, Conjunto Quimicas, 2010)A simple, rapid and reproducible HPLC method was developed for the simultaneous determination of amlodipine and valsartan in their combined dosage forms, and for drug dissolution studies. A C 18 column (ODS 2, 10 mu m, 200 ... -
Hupresin Retains Binding Capacity For Butyrylcholinesterase And Acetylcholinesterase After Sanitation With Sodium Hydroxide
(2017)Hupresin is a new affinity resin that binds butyrylcholinesterase (BChE) in human plasma and acetylcholinesterase (AChE) solubilized from red blood cells (RBC). Hupresin is available from the CHEMFORASE company. BChE in ... -
Growth Inhibitory Activity Of Ankaferd Hemostat On Primary Melanoma Cells And Cell Lines
(2017)Objective: Ankaferd hemostat is the first topical hemostatic agent about the red blood cell–fibrinogen relations tested in the clinical trials. Ankaferd hemostat consists of standardized plant extracts including Alpinia ... -
In Vitro Effects Of Rosmarinic Acid On Glutathione Reductase And Glucose 6-Phosphate Dehydrogenase
(Taylor & Francis Ltd, 2011)Context: Glutathione reductase (GR, NADPH:oxidized glutathione oxidoreductase, E. C 1.6.4.2) is a flavoprotein that catalyzes the NADPH-dependent reduction of oxidized glutathione (GSSG). GR is a crucial enzyme in the ... -
Fetal Allogeneic Umbilical Cord Cell Transplantation Improves Motor Function In Spinal Cord-Injured Rats
(Turkish Neurosurgical Soc, 2010)AIM: The objective of this study was to investigate whether the transplantation of fetal umbilical cord tissue cells as a source of stem cells into the acutely injured spinal cord would produce some regenerations and/or ... -
Evaluation Of Pharmaceutical Quality Of Conventional Dosage Forms Containing Paracetamol And Caffeine Available In The Turkish Drug Market
(Dissolution Technologies, Inc, 2016)The aim of this study was to evaluate the quality of conventional paracetamol- (PA) and caffeine- (CA) containing combined dosage forms in the Turkish drug market. For this purpose, weight variation, content uniformity, ... -
Greater Efficiency Observed 12 Months Post-Implementation Of An Automatic Tube Sorting And Registration System In A Core Laboratory
(2016)Background Sample classification and registration have been recognized as important and time-consuming processes in laboratories. There is increasing pressure on laboratories to automate processes due to intense workload ... -
A New Species of Acantholimon Boiss. (Plumbaginaceae) from Ankara, Turkey
(Wiley-Blackwell, 2002)Acantholimon anatolicum Dogan & Akaydin sp. nov. (Plumbaginaceae) is described and illustrated. The species grows on deep gypsum-rich sandy soil on eroded mountain slopes between Cayirhan and Nallihan in Ankara. Diagnostic ...
