Erişim Hakları "info:eu-repo/semantics/openAccess" Temel Eczacılık Bilimleri Bölümü Makale Koleksiyonu için listeleme
Toplam kayıt 123, listelenen: 61-80
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Induction Of Telomere Dysfunction Mediated By The Telomerase Substrate Precursor 6-Thio-2'-Deoxyguanosine
(Amer Assoc Cancer Research, 2015)The relationships between telomerase and telomeres represent attractive targets for new anticancer agents. Here, we report that the nucleoside analogue 6-thio-2'-deoxyguanosine (6-thio-dG) is recognized by telomerase and ... -
Investigating the Structural Influence of Surface Mutations on Acetylcholinesterase Inhibition by Organophosphorus Compounds and Oxime Reactivation
(Elsevier Ireland Ltd, 2010)Organophosphates (OPs) exert their toxicity by inhibiting primarily acetylcholinesterase (AChE) and to a lesser extent butyrylcholinesterase (BChE). Binary mixtures of mammalian AChE and oximes of varying structure have ... -
Investigation Of Gelatinase Gene Expression And Growth Of Enterococcus Faecalis Clinical Isolates In Biofilm Models
(2019)Objectives: Enterococcus faecalis is the major reason for biofilm-related infections and it also interacts with Staphylococcus aureus in biofilms. Gelatinase (gelE) enzyme is an important virulence factor of E. faecalis ... -
Islamic Fasting Leads To An Increased Abundance Of Akkermansia Muciniphila And Bacteroides Fragilis Group: A Preliminary Study On Intermittent Fasting
(2019)Background/Aims It has been largely accepted that dietary habits affect intestinal microbiota composition. In this pilot study, we hypothesized that time-restricted feeding, which can be regarded as a type of intermittent ... -
Kojic Acid Derivatives As Potential Anticancer Agents: Synthesis And Cytotoxic Evaluation On A375 Human Malignant Melanoma Cells
(2019)Malignant melanoma is a serious type of skin cancer with high mortality rates, arising from melanocytic cells responsible for the pigmentation of the skin. Besides, the excessive accumulation of melanin pigment can lead ... -
Lactoferrin In Gingival Crevicular Fluid And Peripheral Blood During Experimental Gingivitis
(2009)Objectives Lactoferrin (LF) is an iron binding protein and stored in the specific granules of granulocytes. It is released by degranulation following granulocyte activation. A positive correlation was previously reported ... -
Long-Term Effects Of Early-Life Antibiotic Exposure On Resistance To Subsequent Bacterial Infection
(2019)The gastrointestinal microbiota protects hosts from enteric infections; while antibiotics, by altering the microbiota, may diminish this protection. We show that after early-life exposure to antibiotics host susceptibility ... -
Low-Dose Bisphenol A Induces Ripk1-Mediated Necroptosis In Sh-Sy5Y Cells: Effects On Tnf-Alpha And Acetylcholinesterase
(2019)Bisphenol A (BPA) is an endocrine disruptor chemical, which is commonly used in everyday products. Adverse effects of its exposure are reported even at picomolar doses. Effects of picomolar and nanomolar concentrations of ... -
Methamidophos, Dichlorvos, O-Methoate And Diazinon Pesticides Used In Turkey Make A Covalent Bond With Butyrylcholinesterase Detected By Mass Spectrometry
(Wiley, 2010)Organophosphorus pesticides used most commonly in Turkey include methamidophos, dichlorvos, O-methoate and diazinon. These toxic chemicals or their metabolites make a covalent bond with the active site serine of ... -
Misincorporation Of Free M-Tyrosine Cytotoxic Mechanism For Oxidized A Into Cellular Proteins: A Potential Amino Acids
(Portland Press Ltd, 2006)In vitro studies demonstrate that the hydroxyl radical converts L-phenylalanine into in-tyrosine, an unnatural isomer of L-tyrosine. Quantification of m-tyrosine has been widely used as an index of oxidative damage in ... -
Modulation Of Mitochondrial Complex I Activity Averts Cognitive Decline In Multiple Animal Models Of Familial Alzheimer'S Disease
(2015)Development of therapeutic strategies to prevent Alzheimer's disease (AD) is of great importance. We show that mild inhibition of mitochondrial complex I with small molecule CP2 reduces levels of amyloid beta and phospho-Tau ... -
Molecular Fingerprints Of Hemoglobin On A Nanofilm Chip
(2018)Hemoglobin is an iron carrying protein in erythrocytes and also an essential element to transfer oxygen from the lungs to the tissues. Abnormalities in hemoglobin concentration are closely correlated with health status and ... -
Molecular Imprinted Based Quartz Crystal Microbalance Nanosensors For Mercury Detection
(2018)Mercury(II) ions are emerging as a result of more human activity, especially coal‐fired power plants, industrial processes, waste incineration plants, and mining. The mercury found in different forms after spreading around ... -
Molecular Imprinting Applications In Forensic Science
(2017)Producing molecular imprinting-based materials has received increasing attention due to recognition selectivity, stability, cast effectiveness, and ease of production in various forms for a wide range of applications. The ... -
Molecular Imprinting Of Macromolecules For Sensor Applications
(2017)Molecular recognition has an important role in numerous living systems. One of the most important molecular recognition methods is molecular imprinting, which allows host compounds to recognize and detect several molecules ... -
Molecularly Imprinted Biomimetic Surface Plasmon Resonance Sensor For Hormone Detection
(2019)In this study, 17 beta-estradiol (E2) was performed by surface plasmon resonance (SPR) based on molecularly imprinted technique. In the first, SPR sensor was prepared by the formation of E2 imprinted poly(2-hydroxyetyl ...