Prematüre Telarşlı Çocukların Besin Tüketim Durumları ve İştah ile ilgili Parametrelerin Değerlendirmesi
Özet
In recent years, the decline in the average age of puberty has important
public health, clinical, and social implications. The aim of the present study is to
determine the nutritional status and appetite-related peptids in girls diagnosed with
premature thelarche. Forty-four girls aged 4- 8 years who were diagnosed with
premature thelarche (PT) and thirty-three age-matched healthy controls were included
in the study. The participant’s general characteristics, physical activity, and eating
habits were asked by using a questionnaire. Dietary intake of participants were
assessed using a 24-hour recall and food frequency questionnaire. Anthropometric
measurements and bioelectrical impedance analysis of the participants were taken and
blood samples were collected. At the end of the study; It was determined that the PT
group more often tended to purchase food from school canteen (p< 0.05). Bodyweight,
height, body mass index, body fat mass, lean body mass, lean body mass index, upper
mid-arm circumference, and basal metabolic rate of PT group was higher than control
group (p< 0.05). Daily consumption of dairy and fat group were significantly higher
in PT group (p< 0.05). Daily intake of energy (kcal), carbohydrate, protein, and fat
were statistically higher in the PT group compared with the control group (p<0.01).
Serum leptin (p<0.001), nesfatin-1 (p=0.001), and orxein A (p<0.001) levels were
significantly higher in PT and group. However, there were no differences between the
groups for serum ghrelin levels (p>0.05). The results of this study indicate that
excessive dietary energy intake and obesity are likely to effect on PT pathogenesis and
pubertal development. Furthermore, our findings suggest that nesaftin-1 and orexin A
levels may have a similar effect of leptin in the initiation of puberty. For calrifying the
role of nutrition on puberty further prospective and large-scale studies are needed.
Also, future studies are recommended to examine the relationship between nesfatin-1
and orexin A levels with the age of onset of puberty.
