Browsing Eczacılık Meslek Bilimleri Bölümü Tez Koleksiyonu by Type "info:eu-repo/semantics/doctoralThesis"
Now showing items 21-40 of 71
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Halk İlacı ve Gıda Olarak Kullanılan Prunus Mahaleb L. Tohum ve Meyve Kabuklarında Farmakognozik Araştırmalar
(Sağlık Bilimleri Enstitüsü, 2020)Prunus mahaleb L. (syn. Cerasus mahaleb L. Mill.), a member of medicinal plant kingdom, is known as mahlep, mehlep, idris ağac or pis agac and the seeds used as food and exported. In the present study, In our thesis, ... -
Hekzahidrokinolin Türevlerinin Sentezi, Sitotoksik Özelliklerinin, ROS Oluşturma Potansiyellerinin ve Enflamasyon Mediyatörleri Üzerine Etkilerinin İn Vitro Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2022)In this study, novel 24 compounds with alkyl 2,6,6-trimethyl-4-(disubstituted phenyl)-5-oxo- 1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (Compound 1a-1f, 2a-2f, 3a-3f and 4a-4f) structure which is expected to show ... -
Inula Fragılıs Boıss. & Hausskn. Üzerinde Farmakognozik Araştırmalar
(Sağlık Bilimleri Enstitüsü, 2023)Uzun, K., Pharmacognosical studies on Inula fragilis Boiss. & Hausskn., Hacettepe University, Graduate School of Health Sciences, Pharmacognosy Program, PhD Thesis, Ankara, 2023. Inula L. (Asteraceae) species are rich in ... -
Investigation of Intracellular Mechanisms of Sphingosine-1-Phosphate (S1P)-Induced Contractions in Detrusor Smooth Muscle of Rats having Cyclophosphamide-Induced Cystitis
(Sağlık Bilimleri Enstitüsü, 2017)Anjum I., Investigation of Intracellular Mechanisms of Sphingosine-1-Phosphate (S1P)-Induced Contractions in Detrusor Smooth Muscle of Rats having Cyclophosphamide-Induced Cystitis, Hacettepe University, Institute of Health ... -
Investigation of Possible Protective Effects of Certain Xenobiotics on Aluminum Toxicity in SH-SY5Y Cell Line
(Sağlık Bilimleri Enstitüsü, 2023-11-16)Aluminum, a neurotoxic metal, is widely present in our daily lives, exposing us extensively. Aluminum exposure is a potential Alzheimer's risk factor, with no cure yet. Researchers are actively seeking new treatments or ... -
Isolatıon of Potentıal Drug Candıdate Molecules from Rumex Acetosella L. and in Sılıco, in Vıtro Researches on Those Molecules
(Sağlık Bilimleri Enstitüsü, 2018)Ozenver, N., Isolation of Potential Drug Candidate Molecules From Rumex acetosella L. and In Silico, In Vitro Researches on Those Molecules, Hacettepe University, Institute of Health Sciences, Pharmacognosy Program, Doctor ... -
İlaç Hammaddesi Kaynağı Bazı Scutellaria L. Türleri Üzerinde Farmakognozik Araştırmalar
(Sağlık Bilimleri Enstitüsü, 2018-01)Genus Scutellaria (Lamiaceae), which includes about 350 species in worldwide, is widespread in Europe, America and East Asia. It is represented by 16 species in the flora of Turkey. Scutellaria species are the most popular ... -
İmidakloprid ve Asetamipridin İn Vitro Sistemler Üzerindeki Toksik Etkilerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2022-06-27)Neonicotinoids, which have received attention in recent years due to their toxic effects on non-target organisms, particularly bees, are a nicotine-derived insecticide group that is widely used in many countries, including ... -
İnsan Mide Adenokarsinoma Hücrelerinde Helicobacter Pylori'nin Neden Olduğu DNA Çift Sarmal Kırıkları ve Oksidatif Stresin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2019-09-27)Didem, O. Evaluation of DNA Double-Strand Breaks and Oxidative Stress caused by Helicobacter pylori in Human Adenogastric Carcinoma Cells. Hacettepe University Graduate School of Health Sciences, Pharmaceutical Toxicology ... -
Kanser Hastalarında Erişkin Aşılamada Tutum ve Davranışlar Üzerine Etki Eden Faktörlerin Belirlenmesi ve Eczacı Tarafından Verilen Aşı Eğitiminin Etkisinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2022)Intended vaccination rates with the pneumococcal vaccine in cancer patients have not been reached worldwide. This study was aimed to evaluate the impact of clinical pharmacist-provided education on pneumonia and pneumococcal ... -
Karbonmonoksit Zehirlenmesi Olan Çocuklarda Oksidan ve Antioksidan Parametrelerin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2017-06)Carbon monoxide (CO) is a colourless, smell-free, toxic gas. Carbon monoxide poisoning (COP) is one of the most important causes of morbidity and mortality. The balance between the production of free radicals and antioxidant ... -
Kardiyak Cerrahi Hastalarında Preoperatif ve Postoperatif Dönemde Risk Analizi ile İlaç Tedavisinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2023)This study aimed to identify drug related problems (DRPs), analyze the risks and evaluate the impact of a clinical pharmacist in risk management process of cardiac surgery. Prospective, quasi-experimental study was conducted ... -
Kardiyovasküler Toksisite Olasılığı Bulunan Bazı İlaçlar Ile Zehirlenmelerin Beyin Natriüretik Peptid Düzeyi Ile Ilişkisi
(Sağlık Bilimleri Enstitüsü, 2014)Nowadays, referrals to emergency departments due to intoxication remains to be important in terms of mortality and morbidity. Among these intoxications, cases with cardiac involvement should be closely monitored. ... -
Kaynak İşçilerinde Mesleki Maruziyete Bağlı Olası Oksidatif Stres Göstergelerindeki Değişikliklerin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2018-07-05)In recent years, the welding, which is an easier and faster technique than the mechanical methods in cutting and joining metals, is widely used by the manufacturers and repairers. The main potential hazards in welding are; ... -
Kaynak İşçilerinde Mesleki Maruziyete Bağlı Olası Toksik Etkilerin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2018-07-27)Aksu, İ., Evaluation of Possible Genotoxic Damage in Welders Due to Occupational Exposure, Hacettepe University Institute of Health Sciences, Ph.D. Thesis in Pharmaceutical Toxicology, Ankara, 2018. Welding is widely applied ... -
Kojik Asit Türevi Mannich Bazlarının Sentezi ve İnsan Melanoma Hücrelerine Etkisi ile Antitirozinaz Aktivitelerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2017)Malign melanoma is malign tumour of melanin pigment, which gives colour of skin, eyes and hair. It has an increasing rate of incidence and high mortality. Tyrosinase is the enzyme responsible for melanin production in ... -
Kronik Levetirasetam Uygulanan Normal ve Temporal Lob Epilepsi Modeli Oluşturulmuş Sıçanlarda Aromataz Ekspresyonu Değişiklikleri
(Sağlık Bilimleri Enstitüsü, 2015)Temporal lobe epilepsy (TLE) model was generated at male Wistar rats by intraperitoneal (i.p.) injection of excitotoxic agent kainic acid (KA). This thesis work has been done as to investigate possible side-effects on ... -
Lavandula stoechas L. subsp. stoechas Üzerinde Biyolojik Aktivite Rehberli Çalışmalar
(Sağlık Bilimleri Enstitüsü, 2023)Lavandula stoechas L. subsp. stoechas known as “karabaş otu” is used for diabetes and central nervous system disorders. This thesis focuses on scientifically validating the traditional usage of L. stoechas subsp. stoechas ... -
Mermer İşçilerinde Genotoksik Etki Mekanizmalarının ve Oksidatif Stres ile İlişkili Değişikliklerin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2021)Workers working in marble processing plants are exposed to high levels of respirable marble dust (<10 μm) in processes such as cutting, polishing, shaping. Marble dust is mainly composed of calcium carbonate and contains ... -
Metforminin Sitotoksik, Apoptotik ve Genotoksik Etkilerinin İn Vitro Değerlendirilmesi.
(Sağlık Bilimleri Enstitüsü, 2018)Metformin is a biguanide derivative widely used in the treatment of diabetes mellitus. Recent studies have shown the anticancer properties of metformin. The possible mechanisms of anticancer effects of metformin have ...