Tip II Diyabetli Hastalarda Beslenme Durumu ile Kanda CD36 Yağ Asit Transport Düzeyi ve Bazı İnflamasyon Belirteçleri Arasındaki İlişkinin Değerlendirilmesi

Abstract

Ekici, E.M., Investigating the Relationship of Nutritional Status with Blood CD36 Fatty Acid Transport Receptor Levels and Some Inflammation Markers in Type II Diabetes Patients, Hacettepe University, Graduate School of Health Sciences, Nutrition and Dietetics Programme, PhD Thesis, Ankara, 2021. This study was planned to investigate the relationship between the nutritional statuses of individuals including those diagnosed with type II diabetes mellitus (T2DM), those diagnosed with prediabetes and those in the control group and their blood CD36 fatty acid transport receptor levels and some inflammation markers. This study was carried out with 81 individuals at the ages of 25-65 who presented to the Endocrinology Outpatient Clinic of the Department of Internal Medicine at the Faculty of Medicine at Kırıkkale University including 27 individuals diagnosed with T2DM (female: 18, male: 9), 27 individuals with prediabetes (female: 18, male: 9) and 27 individuals without any disorder (female: 18, male: 9). Information was collected from the individuals in person on their sociodemographic characteristics, physical activity statuses and 24-hour retrospective food consumption records for determining their nutritional status, and their anthropometric measurements were taken. Besides the routine blood parameters on which information was obtained from patient files, one tube of fasting blood sample was taken from each participant, and in the sera of these blood samples, CD36, CRP, adiponectin, leptin, omentin, TNF-α and insulin levels were measured. According to the results of the analyses carried out in the study, the blood CD36, glucose, triglyceride, HbA1c, CRP and TNF-α levels and HOMA-IR, TyG-index and sCD36 index levels in the T2DM group were found to be higher, and their blood omentin levels were found to be lower in comparison to the other groups (p<0.05). In this study, the ratio of the energy intake of the control group coming from MUFA was found to be higher than those of the other groups (p<0.05). The CD36 levels of the individuals in the T2DM group were moderately and positively related to their amounts of cholesterol and animal protein taken with diet and moderately and negatively related to their total fiber, soluble and non-soluble fiber intake values. In the study, there was a positive significant relationship between CD36 levels and TNF-α in all three groups (p<0.05). Consequently, while CD36 levels are an important parameter for T2DM, they may be associated with nutrients taken with diet and inflammation markers affecting T2DM.