Show simple item record

dc.contributor.authorIoele, Giuseppina
dc.contributor.authorGündüz, Miyase Gözde
dc.contributor.authorSpatari, Claudia
dc.contributor.authorDe Luca, Michele
dc.contributor.authorGrande, Fedora
dc.contributor.authorRagno, Gaetano
dc.date.accessioned2021-06-03T08:50:28Z
dc.date.available2021-06-03T08:50:28Z
dc.date.issued2019
dc.identifier.issn1999-4923
dc.identifier.urihttp://dx.doi.org/10.3390/pharmaceutics11010028
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359235/
dc.identifier.urihttp://hdl.handle.net/11655/24345
dc.description.abstractThe stability profile of a new 1,4-dihydropyridine derivative (DHP), representative of a series with a hexahydroquinoline ring, was studied to design light-stable liquid formulations. This molecule, named M3, has been shown among the analogs to have a high capacity to block both L- and T-type calcium channels. The ethanol solution of the drug was subjected to a photodegradation test, in accordance with standard rules. The concentrations of the drug and its byproducts were estimated using multivariate curve resolution, applied to the spectral data collected during the test. The improvement of both the photostability and water solubility of M3 was investigated by adding the surfactant polysorbate 20 in a 1:5 ratio to aqueous solutions of the drug. These formulations were exposed to stressing light in containers of bleu polyethylene terephthalate (PET), amber PET, and covered amber PET. The best results were obtained when using the covered amber PET container, reaching a degradation percentage of the drug less than 5% after 12 h under an irradiance power of 450 W/m2. The stability of the compound was compared to that of nimodipine (NIM) under the same conditions.
dc.language.isoen
dc.relation.isversionof10.3390/pharmaceutics11010028
dc.rightsAttribution 4.0 United States
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleA New Generation Of Dihydropyridine Calcium Channel Blockers: Photostabilization Of Liquid Formulations Using Nonionic Surfactants
dc.title.alternativeA New Generation of Dihydropyridine Calcium Channel Blockers
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalPharmaceutics
dc.contributor.departmentFarmasötik Kimya
dc.identifier.volume11
dc.identifier.issue1
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus


Files in this item

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 United States
Except where otherwise noted, this item's license is described as Attribution 4.0 United States