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dc.contributor.authorTanyeli, Talip Talha
dc.contributor.authorKaradaş, Hatice
dc.contributor.authorAkyıldız, İlker
dc.contributor.authorGökdoğan, Ozan
dc.contributor.authorSönmez, Çiğdem
dc.contributor.authorCavuş, Mehmet Emin
dc.contributor.authorKaptan, Zeynep
dc.contributor.authorUzunkulaoğlu, Hakkı
dc.contributor.authorArslan, Necmi
dc.contributor.authorZeybek, Naciye Dilara
dc.date.accessioned2021-06-03T06:03:29Z
dc.date.available2021-06-03T06:03:29Z
dc.date.issued2019
dc.identifier.issn1308-7649
dc.identifier.urihttp://dx.doi.org/10.5152/iao.2019.6208
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750776/
dc.identifier.urihttp://hdl.handle.net/11655/24177
dc.description.abstractOBJECTIVES The aim of our study was to investigate the effects of folic acid on cisplatin-induced ototoxicity. MATERIALS and METHODS Thirty Wistar albino rats were divided into five groups. Group I received intraperitoneal cisplatin (IP) 10 mg/kg/day and IP folic acid 10 mg/kg/day; Group II received IP cisplatin 10 mg/kg/day and IP physiological saline; Group III received IP cisplatin 10 mg/kg/day and intratympanic (IT) folic acid 0.15 mL/day; Group IV received IP cisplatin 10 mg/kg/day and IT physiological saline; and Group V received IT folic acid 0.15 mL/day. Before and after drug administration, plasma homocysteine, folic acid levels, and auditory brainstem evoked responses (ABR) were measured. The rats were then sacrificed, and the inner ears were processed for electron microscopy. RESULTS The differences of ABR thresholds in Group I compared to Group II were significantly smaller at 4 kHz, 8 kHz, and 16 kHz, whereas they were smaller but not statistically significant at 12 kHz in ABR. The differences of ABR thresholds in Group III compared to Group IV were significantly smaller at 12 kHz, and smaller but not statistically significant at 4 kHz, 8 kHz, and 16 kHz. Cisplatin treatment resulted in the degeneration of the cells of the organ of Corti, stria vascularis, and spiral ganglion. The cells of the organ of Corti, stria vascularis, and spiral ganglion showed a partially preserved morphology in both Group I and Group III. CONCLUSION Our study results suggests that folic acid is a potential agent in preventing cisplatin-induced ototoxicity.
dc.language.isoen
dc.relation.isversionof10.5152/iao.2019.6208
dc.rightsAttribution 4.0 United States
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleEffect Of Folic Acid On Cisplatin-Induced Ototoxicity: A Functional And Morphological Study
dc.title.alternativeEffect of Folic Acid on Cisplatin-Induced Ototoxicity
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalThe Journal Of International Advanced Otology
dc.contributor.departmentHistoloji ve Embriyoloji
dc.identifier.volume15
dc.identifier.issue2
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus


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Attribution 4.0 United States
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