dc.contributor.author | Colpak, Ayse Ilksen | |
dc.contributor.author | Sevim, Duygu Gulmez | |
dc.contributor.author | Tuncer, Asli | |
dc.contributor.author | Diker, Sevda | |
dc.contributor.author | Karabudak, Rana | |
dc.contributor.author | Kadayificilar, Sibel | |
dc.contributor.author | Kansu, Tulay | |
dc.date.accessioned | 2021-06-03T05:42:55Z | |
dc.date.available | 2021-06-03T05:42:55Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1301-062X | |
dc.identifier.uri | http://dx.doi.org/10.4274/tnd.galenos.2018.33230 | |
dc.identifier.uri | http://hdl.handle.net/11655/24102 | |
dc.description.abstract | Objective: To compare the peripapillary retinal nerve fiber layer (pRNFL) thickness and macular volume in patients with multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), and healthy controls. Materials and Methods: This study used spectral domain-optical coherence tomography to measure pRNFL and the volume of retinal layers at the macula. Forty patients with MS or NMOSD and 19 healthy controls were enrolled. Results: After at least one clinical episode of optic neuritis, the average pRNFL for NMOSD [60 mu m (34-105)] and patients with MS [85 mu m (41-109)] were lower than in healthy controls [99 mu m (88-109)], and patients with NMOSD had significantly lower pRNFL compared with patients with MS (p=0.002). Foveal volume did not differ between optic neuritis eyes of patients with NMOSD and MS (NMOSD 1.18 +/- 0.3 mm(3), MS 1.82 +/- 2.07 mm(3)). The mean pRNFL values in seroneguive NMOSD eyes [58 mu m (range, 47-111)] tended to be thinner compared with seropositive NMOSD eyes [76 mu m (range, 42-105)]. This finding was not considered to he statistically significant. Conclusion: Our study revealed that both foveal (area in a 1.5 mm ETDRS ring) and coral macular volume (area in a 6 mm ETDRS ring) were lower in both patients with MS and NMOSD compared with healthy controls. Optic neuritis of NMOSD is associated with a thinner average RNFL compared with MS, suggesting earlier axonal injury in the affected optic nerves. | |
dc.language.iso | en | |
dc.relation.isversionof | 10.4274/tnd.galenos.2018.33230 | |
dc.rights | Attribution 4.0 United States | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | optic neuritis | |
dc.subject | optical coherence tomography | |
dc.subject | multiple sclerosis | |
dc.subject | Neuromyelitis optica | |
dc.title | Analysis Of Peripapillary Retinal Nerve Fiber Layer And Macular Volume In Patients With Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, And Healthy Controls Using Spectral Domain Optical Coherence Tomography In A Turkish Cohort | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Turkish Journal Of Neurology | |
dc.contributor.department | Nöroloji | |
dc.identifier.volume | 25 | |
dc.identifier.issue | 1 | |
dc.description.index | WoS | |
dc.description.index | Scopus | |