Basit öğe kaydını göster

dc.contributor.authorBulduk, Erkut Baha
dc.contributor.authorKurt, Gokhan
dc.contributor.authorBarun, Sureyya
dc.contributor.authorAydemir, Onder
dc.contributor.authorKiziltas, Murat
dc.contributor.authorOktem, Murat
dc.contributor.authorTurhan, Turan
dc.contributor.authorAtilla, Pergin
dc.contributor.authorMuftuoglu, Sevda
dc.date.accessioned2021-06-03T05:19:58Z
dc.date.available2021-06-03T05:19:58Z
dc.date.issued2019
dc.identifier.issn1019-5149
dc.identifier.urihttp://dx.doi.org/10.5137/1019-5149.JTN.22744-18.1
dc.identifier.urihttp://hdl.handle.net/11655/23952
dc.description.abstractAIM: To investigate possible correlations between serum S100B levels and microglial/astrocytic activation in status epilepticus (SE) in lithium-pilocarpine-exposed rat hippocampi and whether serum S100B levels linearly reflect neuroinflammation. Additionally, to assess the effects of minocycline (M), an inhibitor of neuroinflammation. MATERIAL and METHODS: Rats were divided into 4 groups (6/group), namely, control (C), sham, SE, and SE+M. Animals were exposed to lithium-pilocarpine to induce SE in the SE and SE+M groups. Cardiac blood was collected to measure S100B levels, and coronal brain sections including the hippocampus were prepared to examine microglial/astrocytic activation and to evaluate neuroinflammation at day 7 of SE. RESULTS: Serum S100B levels, OX42 (+) microglia in CA1, and GFAP (+) astrocytes in both CA1 and dentate gyrus (DG) were higher in the SE+M group than in the C group. Most importantly, highly positive correlations were found between S100B levels and microglial activation in CA1, apart from astrocytic activation in CA1 and DG. Unexpectedly, microglial activation in CA1 and astrocytic activation in DG were also enhanced in the SE+M group compared with the C group. Moreover, M administration reversed the neuronal loss observed in DG during SE. CONCLUSION: These results suggest that serum S100B is a candidate biomarker for monitoring neuroinflammation and that it may also help predict diagnosis and prognosis.
dc.language.isoen
dc.relation.isversionof10.5137/1019-5149.JTN.22744-18.1
dc.rightsAttribution 4.0 United States
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAstrocyte
dc.subjectMicroglia
dc.subjectMinocycline
dc.subjectS100B
dc.subjectSeizure
dc.titleThe Effects Of Minocycline On The Hippocampus In Lithium-Pilocarpine Induced Status Epilepticus In Rat: Relations With Microglial/Astrocytic Activation And Serum Mob Level
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalTurkish Neurosurgery
dc.contributor.departmentİç Hastalıkları
dc.identifier.volume29
dc.identifier.issue1
dc.description.indexWoS
dc.description.indexScopus


Bu öğenin dosyaları:

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster

Attribution 4.0 United States
Aksi belirtilmediği sürece bu öğenin lisansı: Attribution 4.0 United States