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dc.contributor.authorSimsek, Cem
dc.contributor.authorEsin, Ece
dc.contributor.authorYalcin, Suayib
dc.date.accessioned2021-06-03T05:19:52Z
dc.date.available2021-06-03T05:19:52Z
dc.date.issued2019
dc.identifier.issn1687-8450
dc.identifier.urihttp://dx.doi.org/10.1155/2019/5483791
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446118/
dc.identifier.urihttp://hdl.handle.net/11655/23927
dc.description.abstractMetronomic chemotherapy, continuous and dose-dense administration of chemotherapeutic drugs with lowered doses, is being evaluated for substituting, augmenting, or appending conventional maximum tolerated dose regimens, with preclinical and clinical studies for the past few decades. To date, the principle mechanisms of its action include impeding tumoral angiogenesis and modulation of hosts' immune system, affecting directly tumor cells, their progenitors, and neighboring stromal cells. Its better toxicity profile, lower cost, and easier use are main advantages over conventional therapies. The evidence of metronomic chemotherapy for personalized medicine is growing, starting with unfit elderly patients and also for palliative treatment. The literature reviewed in this article mainly demonstrates that metronomic chemotherapy is advantageous for selected patients and for certain types of malignancies, which make it a promising therapeutic approach for filling in the gaps. More clinical studies are needed to establish a solidified role for metronomic chemotherapy with other treatment models in modern cancer management.
dc.language.isoen
dc.relation.isversionof10.1155/2019/5483791
dc.rightsAttribution 4.0 United States
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleMetronomic Chemotherapy: A Systematic Review Of The Literature And Clinical Experience
dc.title.alternativeMetronomic Chemotherapy
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalJournal Of Oncology
dc.contributor.departmentİç Hastalıkları
dc.identifier.volume2019
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus


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Attribution 4.0 United States
Aksi belirtilmediği sürece bu öğenin lisansı: Attribution 4.0 United States