dc.contributor.author | Kiliç, Levent | |
dc.contributor.author | Karadağ, Ömer | |
dc.contributor.author | Erden, Abdulsamet | |
dc.contributor.author | Sari, Alper | |
dc.contributor.author | Armağan, Berkan | |
dc.contributor.author | Yardimci, Gözde Kübra | |
dc.contributor.author | Firat, Esra | |
dc.contributor.author | Kalyoncu, Umut | |
dc.contributor.author | Apraş Bilgen, Şule | |
dc.contributor.author | Kiraz, Sedat | |
dc.contributor.author | Ertenli, Ihsan | |
dc.contributor.author | Akdoğan, Ali | |
dc.date.accessioned | 2021-03-19T06:55:23Z | |
dc.date.available | 2021-03-19T06:55:23Z | |
dc.date.issued | 2020-02-13 | |
dc.identifier.citation | Kiliç L, Karadağ Ö, Erden A, Sari A, Armağan B, Yardimci GK, Firat E, Kalyoncu U, Apraş Bilgen Ş, Kiraz S, Ertenli I, Akdoğan A. Anti-interleukin-6 (tocilizumab) therapy in Takayasu’s arteritis: a real life experience. Turk J Med Sci. 2020 Feb 13;50(1):31-36. doi: 10.3906/sag-1906-39. Epub ahead of print. PMID: 31655524; PMCID: PMC7080363. | tr_TR |
dc.identifier.uri | https://journals.tubitak.gov.tr/medical/issues/sag-20-50-1/sag-50-1-6-1906-39.pdf | |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/31655524/ | |
dc.identifier.uri | https://doi.org/10.3906/sag-1906-39 | |
dc.identifier.uri | http://hdl.handle.net/11655/23591 | |
dc.description.abstract | Background/aim: Tumour necrosis factor inhibitors and anti-interleukin-6 (anti-IL-6) therapies are increasingly being used in Takayasu’s arteritis (TA) patients who are unresponsive to corticosteroids ± conventional immunosuppressive agents. The aim of this study is to assess the efficacy and safety of anti-IL-6 (tocilizumab) therapy in refractory TA patients in real life.
Materials and methods: Fifteen TA patients (86.7% were female) who received at least 3 cycles of tocilizumab therapy were retrospectively assessed by clinical, laboratory, and radiological evaluations before and after tocilizumab therapy.
Results: The median (min–max) age of the patients at evaluation was 35 (20–58) years and the median disease duration from diagnosis was 24 (12–168) months. The median (min.–max.) duration of follow-up after tocilizumab was 15 (3–42) months. There was a significant decrease in erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and patient global visual analogue scale (VAS) scores of patients after tocilizumab therapy. The median (min.–max.) ESR was 26 (5–119) vs. 3 (2–49) mm/h, P = 0.02; CRP was 39.8 (2.4–149.0) vs. 7.9 (0–92.9) mg/L, P = 0.017; and patient global VAS was 50 (0–90) vs. 30 (0–60), P = 0.027, respectively. In 8 patients, ESR and CRP levels were in the normal range in the last control. Imaging modality results after tocilizumab were available for 9 patients; 8 patients were radiologically stable and regression was seen in 1 patient. Comparable imaging modality results before and after tocilizumab were available for 5 patients; 4 patients were radiologically stable and regression was seen in 1 patient. Radiological findings were consistent with laboratory responses. Glucocorticoid dosages decreased from a mean dosage of 16.2 (9.1) mg/day at baseline to 7.1 (3.8) mg/day (P = 0.001) at the last follow-up visit. There was no increase in the steroid dosage in any of the patients. All patients tolerated tocilizumab well.
Conclusion: Based on retrospective real life data, anti-IL-6 (tocilizumab) appears to be an effective and tolerable treatment option in refractory TA patients. | tr_TR |
dc.language.iso | en | tr_TR |
dc.publisher | TÜBİTAK | tr_TR |
dc.relation.isversionof | 10.3906/sag-1906-39 | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | tr_TR |
dc.rights.uri | http://creativecommons.org/publicdomain/zero/1.0/ | * |
dc.subject | Takayasu’s arteritis | tr_TR |
dc.subject | tocilizumab | tr_TR |
dc.subject | Anti-interleukin-6 | tr_TR |
dc.subject.lcsh | Tıp uygulaması | tr_TR |
dc.title | Anti-interleukin-6 (tocilizumab) therapy in Takayasu’s arteritis: a real life experience | tr_TR |
dc.type | info:eu-repo/semantics/article | tr_TR |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Turk J Med Sci | tr_TR |
dc.contributor.department | İç Hastalıkları | tr_TR |
dc.identifier.volume | 50 | tr_TR |
dc.identifier.issue | 1 | tr_TR |
dc.identifier.startpage | 31 | tr_TR |
dc.identifier.endpage | 36 | tr_TR |
dc.description.index | PubMed | tr_TR |
dc.funding | Yok | tr_TR |