Two cases of glutaric aciduria type II: how to differentiate from inflammatory myopathies?
Tarih
2018-11-19Yazar
Koca, Meltem
Erden, Abdulsamet
Armagan, Berkan
Sari, Alper
Yıldız, Fatih
Ozdamar, Sevim
Kalyoncu, Umut
Karadag, Ömer
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Muscle weakness is a nonspecific finding of myopathy of any etiology that include iatrogenic, toxic, endocrinological, infectious, immunologic, and metabolic disorders. Among the metabolic myopathies glutaric aciduria type II (GAII) is an autosomal recessively inherited rare disorder of fatty acid and amino acid metabolisms. The late onset form is heterogeneous in terms of symptomatology and severity and for the cases that chronic manifestations of lipid storage myopathy are the only clues for the disease, differential diagnosis can be challenging. Here we report two cases of GAII: the first one was 18-year old boy who presented with proximal muscle weakness and in another center, he was diagnosed as polymyositis and treated with immunosuppressive therapies. He admitted to our clinic with ongoing muscle weakness and symptoms that were related to the side effects of immunosuppressive therapies. The second case was also presented with muscle weakness. For both cases, muscle biopsies and urinary organic acid analyses were consistent with the diagnosis of GAII. To differentiate inflammatory myositis from non-inflammatory myopathies; rheumatic symptoms, accompanying complaints of the patient and autoantibody positivity can be helpful. To our knowledge this is the first report to underline the differential diagnosis of inflammatory myopathies from metabolic myopathies.
Bağlantı
http://hdl.handle.net/11655/23564https://doi.org/10.1080/17843286.2018.1547244
https://pubmed.ncbi.nlm.nih.gov/30451603/
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Künye
Meltem Koca, Abdulsamet Erden, Berkan Armagan, Alper Sari, Fatih Yildiz, Sevim Ozdamar, Umut Kalyoncu & Omer Karadag (2019) Two cases of glutaric aciduria type II: how to differentiate from inflammatory myopathies?, Acta Clinica Belgica, 74:6, 451-455, DOI: 10.1080/17843286.2018.1547244Aşağıdaki lisans dosyası bu öğe ile ilişkilidir: