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dc.contributor.authorUlum, Baris
dc.contributor.authorTeker, H Taner
dc.contributor.authorSarikaya, Aysun
dc.contributor.authorBalta, Gunay
dc.contributor.authorKuskonmaz, Baris
dc.contributor.authorUckan Cetinkaya, Duygu
dc.contributor.authorAerts Kaya, Fatma
dc.date.accessioned2020-10-21T12:42:35Z
dc.date.available2020-10-21T12:42:35Z
dc.date.issued2018
dc.identifier.issn1097-4652
dc.identifier.urihttp://hdl.handle.net/11655/23025
dc.identifier.urihttps://doi.org/10.1002/jcp.26804
dc.description.abstractBone marrow mesenchymal stem cells (BM‐MSCs) are promising candidates for regenerative medicine purposes. The effect of obesity on the function of BM‐MSCs is currently unknown. Here, we assessed how obesity affects the function of BM‐MSCs and the role of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) therein. BM‐MSCs were obtained from healthy donors with a normal (<25) or high (>30) body mass index (BMI). High‐BMI BM‐MSCs displayed severely impaired osteogenic and diminished adipogenic differentiation, decreased proliferation rates, increased senescence, and elevated expression of ER stress–related genes ATF4 and CHOP. Suppression of ER stress using tauroursodeoxycholic acid (TUDCA) and 4‐phenylbutyrate (4‐PBA) resulted in partial recovery of osteogenic differentiation capacity, with a significant increase in the expression of ALPL and improvement in the UPR. These data indicate that BMI is important during the selection of BM‐MSC donors for regenerative medicine purposes and that application of high‐BMI BM‐MSCs with TUDCA or 4‐PBA may improve stem cell function. However, whether this improvement can be translated into an in vivo clinical advantage remains to be assessed.
dc.language.isoentr_TR
dc.publisherWiley
dc.relation.isversionof10.1002/jcp.26804
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectmesenchymal stem cellstr_TR
dc.titleBone Marrow Mesenchymal Stem Cell Donors with a High Body Mass Index Display Elevated Endoplasmic Reticulum Stress and are Functionally Impairedtr_TR
dc.typeinfo:eu-repo/semantics/articletr_TR
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalJournal of Cellular Physiology
dc.contributor.departmentÇocuk Sağlığı ve Hastalıklarıtr_TR
dc.description.indexWoStr_TR
dc.fundingYoktr_TR


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