A Prompt Graft-Versus-Thalassemia Effect upon Withdrawal of CyclosporineA in A Child Who Received Allogeneic Peripheral Blood Stem Cell Transplantation

Abstract

Stable mixed chimerism is a common event in children with thalassemia major who have undergone bone marrow transplantation (BMT). However, persistence of unstable mixed chimerism in these children is associated with a greater risk of rejection and/or relapse of the disease. Andreani et al.1 has reported that rejection and/or disease recurrence occurs in approximately one third of patients with early mixed chimerism in thalassemia major.