dc.contributor.author | Kolgelier, Servet | |
dc.contributor.author | Ergin, Merve | |
dc.contributor.author | Demir, Lutfi Saltuk | |
dc.contributor.author | İnkaya, Ahmet Çağkan | |
dc.contributor.author | Aktuğ Demir, Nazlım | |
dc.contributor.author | Alışık, Murat | |
dc.contributor.author | Erel, Özcan | |
dc.date.accessioned | 2020-02-04T12:31:38Z | |
dc.date.available | 2020-02-04T12:31:38Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1344-6304 | |
dc.identifier.uri | https://doi.org/10.7883/yoken.JJID.2016.196 | |
dc.identifier.uri | http://hdl.handle.net/11655/22006 | |
dc.description.abstract | The objective of this study was to examine a novel profile: thiol-disulfide homeostasis in acute brucellosis. The study included 90 patients with acute brucellosis, and 27 healthy controls. Thiol-disulfide profile tests were analyzed by a recently developed method, and ceruloplasmin levels were determined. Native thiol levels were 256.72 +/- 48.20 mu mol/L in the acute brucellosis group and 461.13 +/- 45.37 mu mol/L in the healthy group, and total thiol levels were 298.58 +/- 51.78 mu mol/L in the acute brucellosis group and 504.83 +/- 51.05 mu mol/L in the healthy group (p < 0.001, for both). The disulfide/native thiol ratios and disulfide/total thiol ratios were significantly higher, and native thiol/total thiol ratios were significantly lower in patients with acute brucellosis than in the healthy controls (p < 0.001, for all ratios). There were either positive or negative relationships between ceruloplasmin levels and thiol-disulfide parameters. The thiol-disulfide homeostasis was impaired in acute brucellosis. The strong associations between thiol-disulfide parameters and a positive acute-phase reactant reflected the disruption of the balance between the antioxidant and oxidant systems. Since thiol groups act as anti-inflammatory mediators, the alteration in the thiol-disulfide homeostasis may be involved in brucellosis. | tr_TR |
dc.language.iso | en | tr_TR |
dc.publisher | Natl Inst Infectious Diseases | tr_TR |
dc.relation.isversionof | 10.7883/yoken.JJID.2016.196 | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | tr_TR |
dc.subject | Infectious diseases | tr_TR |
dc.subject.lcsh | Mikrobiyoloji | tr_TR |
dc.title | Impaired Thiol-Disulfide Balance In Acute Brucellosis | tr_TR |
dc.type | info:eu-repo/semantics/article | tr_TR |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Japanese Journal Of Infectious Diseases | tr_TR |
dc.contributor.department | Mikrobiyoloji | tr_TR |
dc.identifier.volume | 70 | tr_TR |
dc.identifier.issue | 3 | tr_TR |
dc.identifier.startpage | 258 | tr_TR |
dc.identifier.endpage | 262 | tr_TR |
dc.description.index | WoS | tr_TR |
dc.description.index | Scopus | tr_TR |
dc.funding | Yok | tr_TR |