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dc.contributor.authorBenekli, Mustafa
dc.contributor.authorYalçın, Şuayib
dc.contributor.authorÖzkan, Metin
dc.contributor.authorElkıran, Emin Tamer
dc.contributor.authorSevinç, Alper
dc.contributor.authorÇabuk, Devrim
dc.contributor.authorÇoşkun, Hasan Şenol
dc.contributor.authorÖksüzoğlu, Berna
dc.contributor.authorBayar, Banu
dc.contributor.authorAkbulat, Arif
dc.contributor.authorÖzet, Ahmet
dc.date.accessioned2020-01-29T11:28:41Z
dc.date.available2020-01-29T11:28:41Z
dc.date.issued2014
dc.identifier.issn1178-6930
dc.identifier.urihttps://doi.org/10.2147/OTT.S70670
dc.identifier.urihttp://www.dovepress.com/efficacy-of-sorafenib-in-advanced-differentiated-and-medullary-thyroid-peer-reviewed-article-OTT
dc.identifier.urihttp://hdl.handle.net/11655/21914
dc.description.abstractPurpose: Chronic otitis media with effusion (OME) is the leading cause of hearing loss during childhood. In bacterial etiology of OME, the most frequent pathogens responsible are Haemophilus influenzae followed by Streptococcus pneumoniae and Moraxella catarrhalis . This study aimed at evaluating the accuracy of nasopharyngeal (NP) specimens in the identification of pathogens in the middle ear fluid (MEF) in patients with OME. Materials and Methods: In this cross sectional, case-control study, 95 MEFs and 53 NP secretion specimens were obtained from 53 children. As a control group, 102 NP specimens were taken from children having an operation other than an otological disease. Conventional culture methods and multiplex-PCR method have been used to determine the etiology of OME; NP carriage between cases and control groups were compared using conventional culture methods. Pearson Chi-Square and Fisher's Exact tests were used in statistical analysis. Results : Bacteria were isolated by culture in 37.9% of MEF specimens, 14.7% of which belonged to the group H. influenzae , S. pneumoniae and M. catarrhalis. PCR was positive in 30.5% specimens targeting the same pathogens. There was a two-fold increase in carriage rate of S. pneumoniae and H. influenzae in patients than controls for each pathogen. Conclusion: PCR is a more reliable method to detect middle ear pathogens in MEF in comparison with the conventional culture methods. The NP colonization wasn't found to be an indicator of the pathogen in MEF although middle ear pathogens colonize more in nasopharynx of diseased children.tr_TR
dc.language.isoentr_TR
dc.publisherDovepresstr_TR
dc.relation.isversionof10.2147/OTT.S70670tr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subjectChronic otitis media with effusiontr_TR
dc.subjectHaemophilus influenzaetr_TR
dc.subjectMultiplex-PCRtr_TR
dc.subjectMoraxella catarrhalistr_TR
dc.subjectStreptococcus pneumoniaetr_TR
dc.subject.lcshOnkolojitr_TR
dc.titleEfficacy of Sorafenib In Advanced Differentiated and Medullary Thyroid Cancer: Experience In A Turkish Populationtr_TR
dc.typeinfo:eu-repo/semantics/articletr_TR
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalOncoTargets and Therapytr_TR
dc.contributor.departmentTemel Onkolojitr_TR
dc.identifier.volume27tr_TR
dc.identifier.issue3tr_TR
dc.identifier.startpage237tr_TR
dc.identifier.endpage241tr_TR
dc.description.indexWoStr_TR
dc.description.indexPubMedtr_TR
dc.fundingYoktr_TR


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