Muhtemel Biyolojik Aktif Tetrahidrokarbazol Yapısına Sahip Açil Hidrazon Türevlerinin Sentezi

Abstract

Possessing diverse biological activities of tetrahydrocarbazoles and hydrazones display that new compounds which will be synthesized by these two structure combinations, will be able to have wide range of pharmacological activities. In the literature, hydrazone derivatives having tetrahydrocarbazole moiety were synthesized and it was found that they exhibit antibacterial activity. In this work, different from literature, hydrazone derivatives possessing tetrahydrocarbazole moiety 13a-p were synthesized on the C ring of the tetrahydrocarbazole, not on indol N-H. The chemical structure of the synthesized compounds were characterized by 1H-NMR, APT-NMR IR(ATR) spectroscopy and HRMS(ESI) method.