İdiopatik Trombositopenik Purpura ve Trombotik Trombositopenik Purpura’da Klinik Hemostaz Bozuklukları

Abstract

Thrombocytopenia is an important cause of bleeding. The classical pentadiene of thrombotic thrombocytopenic purpura (TTP) is microangiopathic hemolytic anemia, thrombocytopenia, impaired renal function, fever and neurological disorder and TTP is a rare cause of thrombocytopenia. In this study, clinical hemostasis disorders in Idiopathic Thrombocytopenic Purpura and Thrombotic Thrombocytopenic Purpura, which are two different diseases with thrombocytopenia, will be examined, both before and after treatment. A total of 84 thrombocytopenic patients including 67 idiopathic thrombocytopenic purpura (ITP) and 17 thrombotic thrombocytopenic purpura (TTP) were included in the study. In these two disease groups, many cases were examined, especially demographic features. These were examined and compared with the presence and location of bleeding, the presence and location of thrombosis, both the bleeding and thrombosis, the medical treatment of existing diseases, the amount of hemoglobin seen 1 week and 1 month after splenectomy, leukocyte count, platelet count, creatinine amount. At the same time, in the classical pentad of patients with TTP, MAHA and thrombocytopenia were investigated and compared with which fever, neurological disorder and renal functions were not present. Thrombosis, fever, neurological disorder, and renal function were more common in TTP patients, whereas bleeding was more common in ITP patients. However, it was observed that there was a change in ITP patients compared to the clinical haemostasis disorders observed before treatment. All patients with TTP had MAHA and thrombocytopenia. However, fever was seen in 14 (82.3%) patients, neurological disorder in 13 (76.4%) patients, and renal dysfunction in 6 (35.2%) patients. 7 (41.1%) patients with 5 criteria were diagnosed with TTP; 5 (29.4%) patients with 4 criteria; There were 3 (17.6%) patients with 3 criteria.