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dc.contributor.authorSari, Elif
dc.contributor.authorBakar, Bulent
dc.contributor.authorSarkarati, Bahram
dc.contributor.authorBozdogan, Onder
dc.contributor.authorCavusoglu, Tarik
dc.date.accessioned2019-12-16T10:29:40Z
dc.date.available2019-12-16T10:29:40Z
dc.date.issued2016
dc.identifier.issn1300-0144
dc.identifier.urihttps://doi.org/10.3906/sag-1503-7
dc.identifier.urihttp://hdl.handle.net/11655/20158
dc.description.abstractBackground/aim: The survival of autologous fat graft tissue is dependent on various factors such as vascularization and inflammation. The aim of the present study was to evaluate the possible beneficial effects of low-dose methotrexate (LD-MTX) on fat graft volume and survival. Materials and methods: A total of 13 male Wistar albino rats were divided into two groups, a control group and an LD-MTX group. An autologous fat graft obtained from the inguinal region of each rat was transferred to its back. LD-MTX was administered intraperitoneally in the LD-MTX group once a week for 4 weeks after the surgical procedure. The control group underwent surgery but was not administered MTX. Fat grafts were harvested for analyses. Results: The results showed that 2 months postoperatively the fat graft weights of the control and LD-MTX groups were not significantly different. In addition, the vascularity of the grafts was higher in the LD-MTX group than it was in the control group. The mean lipid peroxidation levels were essentially the same in the two groups, but myeloperoxidation was significantly lower in the LD-MTX group than it was in the other group. Conclusion: The results showed that LD-MTX administration may not preserve the quality and volume of transplanted fat tissue in rats.
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.isversionof10.3906/sag-1503-7
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGeneral & Internal Medicine
dc.titleThe Effect of Low-Dose Methotrexate on Autologous Fat Graft Survival
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalTurkish Journal Of Medical Sciences
dc.contributor.departmentBiyokimya
dc.identifier.volume46
dc.identifier.issue4
dc.identifier.startpage1215
dc.identifier.endpage1222
dc.description.indexWoS
dc.description.indexScopus


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