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dc.contributor.authorOzer, Erdem Kamil
dc.contributor.authorGunduz, Miyase Gozde
dc.contributor.authorEl-Khouly, Ahmed
dc.contributor.authorSara, Mehmet Yildirim
dc.contributor.authorSimsek, Rahime
dc.contributor.authorIskit, Alper Bektas
dc.contributor.authorSafak, Osman Cihat
dc.date.accessioned2019-12-16T10:10:05Z
dc.date.available2019-12-16T10:10:05Z
dc.date.issued2015
dc.identifier.issn1300-0527
dc.identifier.urihttps://doi.org/10.3906/kim-1412-72
dc.identifier.urihttp://hdl.handle.net/11655/20024
dc.description.abstractThis study reports the design, synthesis, and calcium channel modulatory activity evaluation of a series of 14 novel fused 1,4-dihydropyridine derivatives. The molecular design of the compounds was based on modifications of nifedipine, which is a calcium channel blocker. The compounds were achieved by one-pot microwave-assisted reaction of 4,4-dimethyl-1,3-cyclohexanedione, 5-chlorosalicylaldehyde/3,5-dichlorosalicylaldehyde, an appropriate alkyl acetoacetate, and ammonium acetate in ethanol according to a modified Hantzsch reaction. The structures of the compounds were confirmed by spectral methods and elemental analysis. To evaluate their relaxant activities, the maximum relaxant response (E-max) and pD(2) values of the compounds and nifedipine were determined on isolated rat aorta rings. The obtained results indicated that all compounds produced concentration-dependent relaxation on the rings possibly due to the blockade of calcium channels. The E-max values (a measure of efficacy) of five compounds were higher than those of nifedipine.
dc.language.isoen
dc.publisherScientific Technical Research Council Turkey-Tubitak
dc.relation.isversionof10.3906/kim-1412-72
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChemistry
dc.subjectEngineering
dc.titleMicrowave-Assisted Synthesis Of Condensed 1,4-Dihydropyridines As Potential Calcium Channel Modulators
dc.typeinfo:eu-repo/semantics/article
dc.relation.journalTurkish Journal Of Chemistry
dc.contributor.departmentFarmasötik Kimya
dc.identifier.volume39
dc.identifier.issue4
dc.identifier.startpage886
dc.identifier.endpage896
dc.description.indexWoS
dc.description.indexScopus


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