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dc.contributor.authorde Rosa, Viviana
dc.contributor.authorErkekoglu, Pinar
dc.contributor.authorForestier, Anne
dc.contributor.authorFavier, Alain
dc.contributor.authorHincal, Filiz
dc.contributor.authorDiamond, Alan M.
dc.contributor.authorDouki, Thierry
dc.contributor.authorRachidi, Walid
dc.date.accessioned2019-12-16T10:10:04Z
dc.date.available2019-12-16T10:10:04Z
dc.date.issued2012
dc.identifier.issn1071-5762
dc.identifier.urihttps://doi.org/10.3109/10715762.2011.647009
dc.identifier.urihttp://hdl.handle.net/11655/20019
dc.description.abstractEpidemiological studies have demonstrated an inverse relationship between selenium (Se) intake and cancer incidence and/or mortality. However, the molecular mechanisms underlying the cancer chemopreventive activity of Se compounds remain largely unknown. The objective of this study was to investigate the effect of low doses of Se on the stimulation of DNA repair systems in response to four different qualities of DNA damage. P53-proficient LNCaP human prostate adenocarcinoma cells were grown either untreated or in the presence of low concentrations of two Se compounds (30 degrees nM sodium selenite, or 10 mu M selenomethionine) and exposed to UVA, H2O2, methylmethane sulfonate (MMS) or UVC. Cell viability as well as DNA damage induction and repair were evaluated by the alkaline Comet assay. Overall, Se was shown to be a very potent protector against cell toxicity and genotoxicity induced by oxidative stress (UVA or H2O2) but not from the agents that induce other types of deleterious lesions (MMS or UVC). Furthermore, Se-treated cells exhibited increased oxidative DNA repair activity, indicating a novel mechanism of Se action. Therefore, the benefits of Se could be explained by a combination of antioxidant activity, the reduction in DNA damage and the enhancement of oxidative DNA repair capacity.
dc.language.isoen
dc.publisherInforma Healthcare
dc.relation.isversionof10.3109/10715762.2011.647009
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiochemistry & Molecular Biology
dc.titleLow Doses Of Selenium Specifically Stimulate The Repair Of Oxidative Dna Damage In Lncap Prostate Cancer Cells
dc.typeinfo:eu-repo/semantics/article
dc.relation.journalFree Radical Research
dc.contributor.departmentFarmasötik Toksikoloji
dc.identifier.volume46
dc.identifier.issue2
dc.identifier.startpage105
dc.identifier.endpage115
dc.description.indexWoS


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