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dc.contributor.authorGoktas, Emine Firat
dc.contributor.authorBulut, Cemal
dc.contributor.authorGoktas, Mustafa Tugrul
dc.contributor.authorOzer, Erdem Kamil
dc.contributor.authorKaraca, Ragip Ozgur
dc.contributor.authorKinikli, Sami
dc.contributor.authorDemiroz, Ali Pekcan
dc.contributor.authorBozkurt, Atilla
dc.date.accessioned2019-12-16T10:09:57Z
dc.date.available2019-12-16T10:09:57Z
dc.date.issued2016
dc.identifier.issn0008-4166
dc.identifier.urihttps://doi.org/10.1139/cjm-2016-0129
dc.identifier.urihttp://hdl.handle.net/11655/20002
dc.description.abstractThe immunopathogenesis of chronic hepatitis B (CHB) has not been clarified yet. Toll-like receptors (TLR) are a receptor family that initiates immunity with exogenous-endogenous ligands and plays a role in the pathogenesis of infections. In this study, we aimed to investigate the frequency of TLR 3 1377C/T (rs3775290) polymorphism and its role in patients with CHB. We included 50 healthy individuals as control group and 73 active and 43 inactive hepatitis B patients. All DNA samples were isolated from blood samples. For the detection of TLR 3 1377C/T single-nucleotide polymorphism, restriction fragment length polymorphism was used. A statistically significant difference was determined in Hepatitis B virus (HBV) DNA levels of CHB patients with the CC, CT, and TT genotypes (p = 0.013). The highest levels of HBV DNA were detected in individuals with TT genotypes. Additionally, the frequency of CC genotype was higher in the active CHB patients compared with that of the inactive CHB patients (p = 0.044). No statistically significant difference in TLR 3 1377C/T polymorphism was detected between healthy controls and the hepatitis B patients (p = 0.342). In conclusion, HBV DNA level was higher in the individuals with TT genotype, and CC genotype was more frequent in the active CHB patients. These results suggest a possible association between CHB and TLR 3 gene (1377C/T) polymorphism.
dc.language.isoen
dc.publisherCanadian Science Publishing, Nrc Research Press
dc.relation.isversionof10.1139/cjm-2016-0129
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiochemistry & Molecular Biology
dc.subjectBiotechnology & Applied Microbiology
dc.subjectImmunology
dc.subjectMicrobiology
dc.titleInvestigation of 1377C/T Polymorphism of the Toll-Like Receptor 3 Among Patients with Chronic Hepatitis B
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalCanadian Journal Of Microbiology
dc.contributor.departmentFarmakoloji
dc.identifier.volume62
dc.identifier.issue7
dc.identifier.startpage617
dc.identifier.endpage622
dc.description.indexWoS


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