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dc.contributor.authorOzer, Erdem Kamil
dc.contributor.authorGoktas, Mustafa Tugrul
dc.contributor.authorKilinc, Ibrahim
dc.contributor.authorToker, Aysun
dc.contributor.authorBariskaner, Hulagu
dc.contributor.authorUgurluoglu, Ceyhan
dc.contributor.authorIskit, Alper Bektas
dc.date.accessioned2019-12-16T10:09:55Z
dc.date.available2019-12-16T10:09:55Z
dc.date.issued2017
dc.identifier.issn0008-4212
dc.identifier.urihttps://doi.org/10.1139/cjpp-2016-0628
dc.identifier.urihttp://hdl.handle.net/11655/19998
dc.description.abstractTumor necrosis factor-alpha (TNF-alpha) is a pivotal mediator that triggers inflammatory process, oxidative stress, and multiple organ injury in sepsis. We investigated the effects of infliximab on survival, mesenteric artery blood flow (MBF), vascular reactivity, and oxidative and inflammatory injuries in cecal ligation and puncture (CLP)-induced sepsis. Wistar rats were divided into Sham, CLP, Sham+infliximab, and CLP+infliximab subgroups. Twenty-four hours before the operations, rats were injected intraperitoneally with infliximab (7 mg/kg) or vehicle (saline; 1 mL/kg). Twenty hours after the operations, MBF and phenylephrine responses of isolated aortic rings were measured. Tissue damages were examined biochemically and histopathologically. Furthermore, survival rates were monitored throughout 96 h. Infliximab improved survival, mesenteric perfusion, and aortic function after CLP. Increases of serum AST, ALT, LDH, BUN, Cr, and inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6) induced by CLP were blocked by infliximab. Infliximab prevented malondialdehyde elevations in septic liver, lung, spleen, and kidney tissues, as well as glutathione reductions in septic liver, spleen, and kidney tissues. Protective effects of infliximab on multiple organ damage were also observed histopathologically. Infliximab showed protective effects in sepsis due to its improvement effects on mesenteric perfusion, aortic function, and its anti-inflammatory and antioxidative effects.
dc.language.isoen
dc.publisherCanadian Science Publishing, Nrc Research Press
dc.relation.isversionof10.1139/cjpp-2016-0628
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPharmacology & Pharmacy
dc.subjectPhysiology
dc.titleInfliximab Alleviates The Mortality, Mesenteric Hypoperfusion, Aortic Dysfunction, And Multiple Organ Damage In Septic Rats
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalCanadian Journal Of Physiology And Pharmacology
dc.contributor.departmentFarmakoloji
dc.identifier.volume95
dc.identifier.issue7
dc.identifier.startpage866
dc.identifier.endpage872
dc.description.indexWoS


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