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dc.contributor.authorGuvenalp, Zuhal
dc.contributor.authorOzbek, Hilal
dc.contributor.authorYerdelen, Kadir Ozden
dc.contributor.authorYilmaz, Gulderen
dc.contributor.authorKazaz, Cavit
dc.contributor.authorDemirezer, Lutfiye Omur
dc.date.accessioned2019-12-16T10:09:43Z
dc.date.available2019-12-16T10:09:43Z
dc.date.issued2017
dc.identifier.issn1307-6167
dc.identifier.urihttps://doi.org/10.25135/rnp.58.17.03.051
dc.identifier.urihttp://hdl.handle.net/11655/19952
dc.description.abstractFive sesquiterpene coumarin ethers: umbelliprenin, umbelliprenin-10', 11'-monoepoxide, conferone, mogoltacin and feselol were isolated from the fruits of Heptaptera cilicica. Their structures were identified by means of spectroscopic methods. AChE and BuChE inhibitory activities of the compounds were determined by molecular docking method which were confirmed by in vitro experiments. According to molecular docking results, total score of feselol and umbelliprenin were 5.69 and 3.23 kcal/mol against acetylcholinesterase, respectively. Total score for butyrylcholinesterase inhibitory effect of them were 2.76 and 4.99 kcal/mol, respectively. Feselol and umbelliprenin exhibited significantly high inhibitory potency against acetylcholinesterase (IC50 = 1.26 +/- 0.01 and 5.86 +/- 0.03 mu M, respectively) and butyrylcholinesterase (IC50 = 9.98 +/- 0.24 and 1.10 +/- 0.19 mu M, respectively). This is the first report of isolation of natural bioactives obtained from the chloroform extract of Heptaptera cilicica fruits with anticholinesterase activity.
dc.language.isoen
dc.publisherAcg Publications
dc.relation.isversionof10.25135/rnp.58.17.03.051
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPlant Sciences
dc.subjectChemistry
dc.subjectPharmacology & Pharmacy
dc.titleCholinesterase Inhibition And Molecular Docking Studies Of Sesquiterpene Coumarin Ethers From Heptaptera Cilicica
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalRecords Of Natural Products
dc.contributor.departmentFarmakognozi
dc.identifier.volume11
dc.identifier.issue5
dc.identifier.startpage462
dc.identifier.endpage467
dc.description.indexWoS
dc.description.indexScopus


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