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dc.contributor.authorGunduz, Miyase Gozde
dc.contributor.authorAlbayrak, Emine
dc.contributor.authorIsli, Fatma
dc.contributor.authorFincan, Gokce Sevim Ozturk
dc.contributor.authorYildirim, Seniz
dc.contributor.authorSimsek, Rahime
dc.contributor.authorSafak, Cihat
dc.contributor.authorSarioglu, Yusuf
dc.contributor.authorYidirim, Sema Ozturk
dc.contributor.authorButcher, Ray J.
dc.date.accessioned2019-12-16T10:09:30Z
dc.date.available2019-12-16T10:09:30Z
dc.date.issued2016
dc.identifier.issn0352-5139
dc.identifier.urihttps://doi.org/10.2298/JSC151206035G
dc.identifier.urihttp://hdl.handle.net/11655/19917
dc.description.abstractThe present study reports the synthesis, structural characterization and myorelaxant activity evaluation of a series of 16 novel 4-naphthylhexahydroquinoline derivatives. The compounds were achieved by one-pot microwave-assisted method via a modified Hantzsch reaction. The structures of the compounds were confirmed by various spectral methods, such as IR, 1D and 2D NMR techniques and mass analysis. X-Ray studies of compound 10 provided further evidence for the proposed structure. To evaluate their myorelaxant activities, the E-max and pD(2) values of the compounds and nifedipine were determined on isolated rabbit gastric fundus smooth muscle strips. The obtained results indicated that the introduction of long chain alkyl groups, such as the 2-methoxyethyl or 2-(methacryloyloxy)ethyl moiety, to the ester group led to the most active compounds.
dc.language.isoen
dc.publisherSerbian Chemical Soc
dc.relation.isversionof10.2298/JSC151206035G
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChemistry
dc.titleSynthesis, Structural Characterization and Myorelaxant Activity of 4-Naphthylhexahydroquinoline Derivatives Containing Different Ester Groups
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalJournal Of The Serbian Chemical Society
dc.contributor.departmentFarmasötik Kimya
dc.identifier.volume81
dc.identifier.issue7
dc.identifier.startpage729
dc.identifier.endpage738
dc.description.indexWoS
dc.description.indexScopus


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