Basit öğe kaydını göster

dc.contributor.authorGündüz, Miyase Gözde
dc.contributor.authorKaya, Yesim
dc.contributor.authorŞimşek, Rahime
dc.contributor.authorSahin-Erdemli, Inci
dc.contributor.authorŞafak, Cihat
dc.date.accessioned2019-12-16T10:09:30Z
dc.date.available2019-12-16T10:09:30Z
dc.date.issued2016
dc.identifier.issn1735-0328
dc.identifier.urihttps://doi.org/
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316254/
dc.identifier.urihttp://hdl.handle.net/11655/19916
dc.description.abstractThe present study reports a microwave-assisted method for the synthesis of twelve novel tricyclic 1,4-dihydropyridine derivatives in which dimethyl-substituted cyclohexane and / or tetrahydrothiophene rings are fused to the DHP ring. The structures of the compounds were confirmed by spectral methods and elemental analysis. , The potassium channel opening effects of the compounds were determined on rat mesenteric arteries and urinary bladders. The obtained results indicated that some compounds produced mesenteric artery-selective relaxant properties and the effects of these compounds were mediated through ATP-sensitive potassium channels. The replacement of the second tetrahydrothiophene ring with dimethyl-substituted cyclohexane ring led to more active compounds. , Docking studies were carried out to understand the interactions of the compounds with the active site of potassium channel. The unsubstituted nitrogen atom on the 1,4-dihydropyridine ring and one of the sulfonyl oxygens were found to be important for the formation of hydrogen bonds to stabilize the compound in the center of the cavity. The nature and position of phenyl ring substituents were also effective on the activity of the compounds. Finally, a theoretical study was established to predict the ADME of the most active compounds.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleSynthesis And Biological Evaluation Of New Tricyclic Dihydropyridine Based Derivatives On Potassium Channels
dc.typeinfo:eu-repo/semantics/article
dc.relation.journalIranian Journal of Pharmaceutical Research : IJPR
dc.contributor.departmentFarmasötik Kimya
dc.identifier.volume15
dc.identifier.issue4
dc.identifier.startpage763
dc.identifier.endpage775
dc.description.indexPubMed


Bu öğenin dosyaları:

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster